Background: As dyslipidemia is a preventable risk factor for Coronary heart disease (CHD), precise estimation of its prevalence and determinants is crucial for proper development of health actions. This population-based study aimed at investigating the socioeconomic, dietary and psychological determinants of dyslipidemia in Iran. Methods: The data (n=700) for this study were collected in 2015 as a part of the major Lifestyle Promotion Project (LPP) conducted in East Azerbaijan (urban and regional parts). The data for socio-demographic status, dietary information, and physical activity and anxiety levels were collected through validated questionnaires. Then, physical examinations including blood pressure, body mass index (BMI) and conicity index were performed. The levels of serum lipids were measured by enzymatic colorimetric methods. Results: The prevalence of hypercholesterolemia, high LDL-C, hypertriglyceridemia, low HDL-C and dyslipidemia was 29.4%, 10.3%, 62.3%, 41.4%, 83.3% respectively. The mean TC (184.3±41.2 vs. 174.5±38.1 mg/dl), LDL-C (94.6±30.3 vs. 88.1±28.7 mg/dl) and HDL-C (46.7±10.4 vs. 39.5±8.0 mg/dl) in women were significantly higher than men (P<0.05). However, the mean of TG (182.3±119.3 vs. 145.1±87.8 mg/dl) was significantly higher in men compared to women (P<0.05). Obesity, family history of dyslipidemia, sedentary lifestyle, smoking habits, salt intake, and anxiety were risk factors for different components of dyslipidemia in men and women. Conclusion: Dyslipidemia is a major health problem in northwest of Iran. Focusing on screening, regular drug intake, proper nutrition, physical activity, and changing lifestyles of patients with dyslipidemia are essential.

Colorectal cancer (CRC) is one of the most lethal and hard-to-treat cancers in the world, which in its advanced stages, surgery and chemotherapy are the main common treatment approaches. The microRNAs (miRNAs), as novel markers for CRC detection, promote their regulatory effects via the 3′-untranslated binding region (3′-UTR) of target messenger RNA in posttranscriptional regulation of genes and also play a pivotal role in modulating resistance to chemotherapeutic agents. These small noncoding RNAs have also a critical role in CRC stem cells (CRCSCs) regulation, comprising self-renewal, differentiation, and tumorigenesis. Cancer stem cells (CSCs) are distinctive cell types inside a tumor tissue that are believed to derive from normal somatic stem cells. The CSCs have self-renewal abilities, angiogenesis, as well as specific surface markers expression characteristics. Furthermore, they are frequently criticized for tumor maintenance, treatment resistance, tumor development, and distant metastasis. In this review, we discuss the current understandings of CRCSCs and their environment with a focus on the role of miRNAs on the regulation of CSCs and their targeting application in CRC treatment.

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