hMPV has been reported as a respiratory pathogen in HSCT patients. We suggest that hMPV infection should be routinely investigated in this population, mainly in children, to prevent nosocomial transmission during transplant proceedings and to avoid the risk of progressing to complications due to LRTI.
SUMMARYAdenovirus (AdV) respiratory infections are usually described as being associated with high mortality rates. Laboratory diagnosis is essential for the establishment of the appropriate therapy, and for guiding the implementation of preventive measures in order to prevent the spread of the infection. Aiming to analyze the sensitivity and specificity of the laboratorial diagnosis methods available, we compared antigen detection by indirect immunofluorescence assay (IF), and a specific nested polymerase chain reaction (PCR), to detect AdV in respiratory samples collected from patients admitted to hospital with acute respiratory disease. Positive samples were inoculated into a cell culture to confirm the results. We analyzed 381 samples from the nasopharyngeal aspirates collected during the year 2008; of these, 2.6% tested were positive for adenovirus through IF and 10% through PCR; positive isolation was obtained in 40% and 26% of these cases, respectively. Most infected patients were children under six months of age, and despite of the fact that a significant number of patients required intensive care, the mortality rate was low (5%). In conclusion, molecular methods were found to be useful for rapid diagnosis of adenovirus infections with higher sensitivity than antigen detection; their introduction permitted a significant increase in diagnoses of adenovirus infections.
The human metapneumovirus (hMPV), member of the Paramyxoviridae family, has been reported as an important agent involved with acute respiratory infections (ARIs
Este artigo apresenta um modelo de Balanced Scorecard (BSC) proposto para laboratório de análises clínicas, baseado na estratégia de Kaplan e Norton, que apresenta um modelo de gestão em laboratório clínico para empresas de qualquer porte. De acordo com esse modelo, a estratégia é definida em relação a perspectivas financeiras, clientes, processos internos, aprendizado e crescimento. O BSC é um instrumento direcionado para o sistema de gestão estratégica que utiliza indicadores de desempenho baseados em variáveis capazes de interferir direta e indiretamente nas ações da empresa.
ResumoEste artigo apresenta um modelo de Balanced Scorecard (BSC) proposto para laboratório de análises clínicas, baseado na estratégia de Kaplan e Norton, que apresenta um modelo de gestão em laboratório clínico para empresas de qualquer porte. De acordo com esse modelo, a estratégia é definida em relação a perspectivas financeiras, clientes, processos internos, aprendizado e crescimento. O BSC é um instrumento direcionado para o sistema de gestão estratégica que utiliza indicadores de desempenho baseados em variáveis capazes de interferir direta e indiretamente nas ações da empresa.
Palavras-chave: Balanced Scorecard, Gestão laboratorial, Laboratório clínico.
AbstractThis article presents a model of Balanced Scorecard (BSC) proposed for clinical laboratory, based on Kaplan and Norton strategy, which presents a management model for the clinical laboratory business of any size. According to this model, strategy is defined as financial prospects, customers, internal processes, learning and growth. The BSC is an instrument directed to the strategic management system that uses performance indicators based on variables that can affect directly and indirectly in company's stock prices.
Cryolipolysis is a non-invasive technique used to reduce localized body fat mass. The changes in fat percentage have been assessed by many analytical methods, including bioelectrical impedance analysis. The most common effects of cryolipolysis on reducing subcutaneous fat tissue have been addressed but potential changes in biochemical and hematological biomarkers have been not safely approached. This study investigates potential changes in hematological and inflammatory biomarkers following the reduction of body fat mass. A prospective longitudinal approach included a total of 20 participants divided into groups of 5 men and women in each with ages between 25 and 45 years. They were submitted to standard cooling exposure for 60 minutes at -5°C and -10°C with 360° and “shielded” equipment, respectively. The blood samples were analyzed at times T0 (baseline), T1 (2 days), T2 (14 days), T3 (30 days) and T4 (60 days) after the procedure. The percentage of body fat mass were analyzed by bioimpedance at times T0 (baseline), T1(30 days), T2 (60 days), T3 (90 days) and T4 (120 days). No changes in hematological and inflammatory biomarkers serum levels were observed in both temperatures. Bioimpedance analysis revealed a reduction in the percentage of body fat mass only in men, with a decrease of 28 (24.5/ 29.9) compared to 30 (26.2/ 33.30) when submitted to -5°C after 120 days. These findings support that cryolipolysis can be considered an effective and safe method for localized body fat reduction without significant changes in blood biochemical parameters.
Keywords: Biomarkers. Lipids. Body Fat. Bioimpedance.
ResumoA criolipólise é uma técnica não invasiva utilizada para reduzir a gordura corporal localizada. A mudança no percentual de gordura pode ser avaliada de várias formas, incluindo a análise de impedância bioelétrica. Os efeitos mais comuns da criolipólise na redução do tecido adiposo subcutâneo são conhecidos, porém as possíveis alterações nos marcadores bioquímicos e hematológicos ainda não foram abordadas com segurança. Este estudo investiga possíveis alterações em marcadores hematológicos e inflamatórios após a redução da massa de gordura corporal. Uma abordagem prospectiva longitudinal incluiu um total de 20 participantes divididos em 2 grupos de 5 homens e mulheres com idades entre 25 e 45 anos. Os participantes foram submetidos à exposição padrão de resfriamento por 60 minutos a temperatura de -5°C e -10°C com os equipamentos “360°” e “blindado” respectivamente. As amostras de sangue foram analisadas nos tempos T0 (basal), T1 (2 dias), T2 (14 dias), T3 (30 dias) e T4 (60 dias) após o procedimento. O percentual de massa gorda corporal foi analisado por bioimpedância nos tempos T0 (basal), T1(30 dias), T2 (60 dias), T3 (90 dias) e T4 (120 dias). Não foram observadas alterações nos níveis séricos de biomarcadores hematológicos e inflamatórios em ambas as temperaturas. A análise de bioimpedância revelou redução do percentual de massa gorda apenas nos homens com diminuição de 28 (24,5/ 29,9) em relação a 30 (26,2/ 33,30) quando submetido a -5°C após 120 dias. Os resultados obtidos sustentam a criolipólise como um método eficaz e seguro para redução da gordura corporal localizada sem alterações significativas nos parâmetros bioquímicos sanguíneos.
Palavras-chave: Biomacadores. Lipídeos. Gordura Corporal. Bioimpedância
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