Adenovirus Respiratory Infection: Significant Increase in Diagnosis Using PCR Comparing With Antigen Detection and Culture Methods

Abstract

SUMMARYAdenovirus (AdV) respiratory infections are usually described as being associated with high mortality rates. Laboratory diagnosis is essential for the establishment of the appropriate therapy, and for guiding the implementation of preventive measures in order to prevent the spread of the infection. Aiming to analyze the sensitivity and specificity of the laboratorial diagnosis methods available, we compared antigen detection by indirect immunofluorescence assay (IF), and a specific nested polymerase ch…