Chemotherapies, HIV infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single-agent therapies are susceptible to failure due to either inherent or acquired resistance, alternative therapeutic approaches such as multi-agent therapies are needed. We have developed a bioinformaticsdriven approach that efficiently predicts compound synergy for such combinatorial therapies. The approach uses chemogenomic profiles in order to identify compound profiles that have a statistically significant degree of similarity to a fluconazole profile. The compounds identified were then experimentally verified to be synergistic with fluconazole and with each other, in both Saccharomyces cerevisiae and the fungal pathogen Candida albicans. Our method is therefore capable of accurately predicting compound synergy to aid the development of combinatorial antifungal therapies.

Endovascular revascularization procedures for PAD cost the health payer less compared with open surgery and primary amputation. While devices used to deliver contemporary endovascular therapy are more expensive, the reduction in bed days, ICU utilization, and related hospital resources results in a significantly lower mean total cost per admission for the initial treatment.

A high prevalence of dental anomalies was observed in this sample of children with UCLP.

Cleft lip and palate (CLP) is the most common craniofacial abnormality and the fourth most common birth defect in Singapore. Many reports suggest that CLP children have delayed dental development and asymmetrical timing of tooth-pair formation. The aim of this study was to investigate the timing of development of permanent teeth in unilateral CLP (UCLP) children and to compare the findings with non-CLP children in Singapore. A total of 60 UCLP children aged between 5 and 9 years (mean 6.64 ± 0.90 years) and a non-CLP control group matched for age, gender, and race were investigated and compared. Dental records and radiographs were studied and the dental maturation was determined using the Demirjian's method (1973). The dental maturation of UCLP children were delayed compared with non-CLP children by a mean of 0.55 ± 0.75 years and the delay was statistically significant (P < 0.001). The UCLP group also had significantly higher risk of asymmetrically developing tooth pairs than the control group (P < 0.001). The most commonly delayed tooth in development was the maxillary cleft-sided lateral incisor. In conclusion, the UCLP children in Singapore demonstrated delayed dental maturation and a higher occurrence of asymmetrical tooth-pair formation than the non-CLP children.