Synthesis of aldol adducts has been accomplished with moderate to excellent stereoselectivities using a Ru III /(S)-BINAP system at room temperature. Under ultrasound irradiation, the aldol products produced in a reasonably short time.
A new method for the synthesis of aldol products is described. The reaction of aromatic and heteroaromatic aldehydes with 1-(thiophen-2-yl)ethanone in the presence of ruthenium chloride hydrate combined with ligand provided the related aldol adducts, in a short time at room temperature in good yields (77-84%).
Catalytic amounts of ruthenium (II) catalyzed the efficient cross aldol reactions of aryl alkyl ketones with aromatic and heteroaromatic aldehydes without the presence of any dehydrated product. The resulted conditions led to the corresponding aldol products in moderate to good yields. Under microwave irradiation, the reaction conditions were improved.
RuIII -catalyzed regio-and diastereoselective direct aldol reaction of progesterone with aromatic aldehydes has been developed in good yields (58-78%). Advantages of this method include catalytic efficiency, short reaction times, and ease of operation and workup.
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