Ruthenium-catalyzed cross aldol reaction with aldehydes and ketones

Abstract

Catalytic amounts of ruthenium (II) catalyzed the efficient cross aldol reactions of aryl alkyl ketones with aromatic and heteroaromatic aldehydes without the presence of any dehydrated product. The resulted conditions led to the corresponding aldol products in moderate to good yields. Under microwave irradiation, the reaction conditions were improved.

Simple and fast microwave-assisted ruthenium_catalyzed direct aldol reaction

“…In continuation of our research in environmentally benign [16][17][18] and microwave-assisted conditions 19 , we now report an operationally simple and fast method for the preparation of aldol products by one-pot condition reaction. We have previously reported this work 17 at room temperature that in all cases, the reaction produced the aldol products with longer reaction times (0.5-2.5 h).…”

Ruthenium-Catalyzed C–H Activation of Salicylaldehyde and Decarboxylative Coupling of Alkynoic Acids for the Selective Synthesis of Homoisoflavonoids and Flavones

“…In the presence of ruthenium and a base, salicylaldehyde reacts with arylpropiolic acid to provide the chalcone intermediate A . This intermediate is converted to flavone B in t -AmOH; however, chromanone was formed in DMSO and further reacts with aldehyde to give the intermediate E through dehydration in DMSO as ruthenium catalyzed cross aldol reaction . Finally, intermediate E was transformed to homoisoflavonoid through rearrangement .…”