Introduction and Aim: Asprosin is a novel fasting-induced glucogenic adipokine, which stimulates the liver to release glucose into the blood stream. The aim of this study was to examine the role of asprosin as well as various physiological and oxidative stress factors in atherosclerosis and myocardial infarction patients in comparison to healthy controls in Kirkuk city, in order to clarify whether asprosin helps in protecting heart and preventing heart disease. Materials and Methods: This study included blood samples collected from patients (n=70) and normal healthy controls (n=20), aged between 45-65 years from the Kirkuk General Hospital and external specialized clinical between December 2021 to February 2022. The samples were divided into three groups which included healthy controls (n=20), patients suffering from atherosclerosis (n=40) and myocardial infarction (n=30) respectively. Individuals in all groups were tested for their blood ASP, CPK-BM Tnt and lipid profile levels. Blood serum was also tested for concentration of FBS, INS, HbA1c, MDA and GSH. Results: The asprosin, CPK-BM, Cardiac troponin (TNt) and INS levels was observed to be significantly elevated in atherosclerosis patients in comparison to healthy controls. However, in myocardial infarction patients significant increase levels was seen only for CPK-BM and INS levels. Lipid profiling showed that except for HDL levels, significant increased levels for TC, TG, LDL and VLDL in both atherosclerosis and MI patients as compared to healthy individuals. The concentration of FBS was seen elevated in blood serum of atherosclerosis and MI patients in comparison to controls. No significant increase was observed for HbA1c and oxidative stress hormones MDA and GSH). Conclusion: Changes in asprosin levels in patients with cardiovascular disease could be considered as a biochemical marker to estimate the severity of injury in heart and heart muscles.
The current study was designed to detect the role of a number of chemical variables represented by fasting blood sugar, hemoglobin A1c and insulin and oxidative stress factors in atherosclerosis patients. The present study involved (70) blood samples aged between (35-65) years the first group involved (40) blood samples from atherosclerosis patients and the second group involved (30) blood samples from healthy individuals, the samples were collected from respondents at Kirkuk General Hospital and Azadi Teaching Hospital in Kirkuk for a while 2021/12/22 to 2022/2/8 and the samples were taken after eight hours of fasting and all the information was taken from the reviewers by means of a questionnaire that included age, body mass index, systolic pressure and diastolic pressure and the results were as follows: significant increase in body mass index in the group of atherosclerosis patients compared to a healthy control group at a significant level (p 0.05) and 55% of them had elevated systolic pressure rate and 40% of them had high diastolic pressure ,the results from the current study show a significant increase in the concentration of asprosin compared to the control group at a significant level (p 0.05),the results of cardiac troponin(t) show a significant increase in the concentration of troponin in the patients of atherosclerosis compared to the control group at a significant level (p 0.05). The results of the study biochemical variables have shown significant increase in fasting blood sugar in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05) and the results of glycated hemoglobin Test (A1c) showed a significant increase in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05) and the results of insulin showed a significant increase in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05). While the results of the study of the oxidative stress which included the glutathione and malondialdehyde there was insignificant reduction in serum concentration of GSH in atherosclerosis patients at a significant level (p 0.05) compared to a control group, and it has also been noted that was a significant increase in serum concentration of MDA in the atherosclerosis patients compared to a control group at a significant level (p 0.05).
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