Introduction. Due to the constant presence of harmful chemical components in the air of the working area at an oil-producing enterprise, the length of work experience exacerbates their negative impact on the human body, which can lead to dysmetabolic disorders. The purpose of the work is to assess changes in the biochemical parameters of metabolism in workers of an oil producing enterprise. Materials and methods. A study and assessment of the content of polycyclic aromatic hydrocarbons in the bioenvironments of workers, biochemical indicators of metabolic processes, statistical analysis, modelling of cause-and-effect relationships were carried out. Results. In oil and gas production operators, benzene and o-xylene are identified in the blood, the concentration of which is up to 1.5 times higher than that of workers not associated with the oil production process. There is and gain in the level of benzene in the blood up to 1.4 times, depending on the increase in work experience. Significant differences were found in the content of C-peptide, glucose, total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides in oil and gas production operators relative to similar indicators in workers not exposed to chemical production factors of the enterprise. Among workers involved in oil and gas production, a dependence of an elevation of glucose and C-peptide in the blood serum on an increase in the concentration of benzene in the blood and the length of work experience was established; an increase in the level of total cholesterol, LDL cholesterol, triglycerides in the blood serum - only depending on the increase in work experience. Limitations. The conducted study takes into account the influence of only chemical factors and the duration of work experience on the health of oil production workers. Conclusions. The constant presence of polycyclic aromatic hydrocarbons in the air, in particular benzene and O-Cixille (up to 1.5 times higher than the MPC of the working area), leads to their increased concentration in the blood. In operators of oil and gas production there was established an increase in the level of a number of biochemical indicators of the negative effects of metabolic syndrome, which are dependent on the length of service and the content of benzene in the air of the working area.
In the process of sustainable development of regions, negative consequences arise in the form of (1) depletion of natural and energy resources, (2) reduction of biological diversity, (3) violation of the stability of ecosystems, and (4) pollution of environmental objects, including atmospheric air. The constant prolonged chronic aerogenic impact of aromatic hydrocarbons on the human body can make a significant contribution to the formation of additional morbidity and mortality in the population. The ability to neutralize and correct the effect of these compounds is ensured not only by continuous monitoring of the quality of atmospheric air and its impact on human health but also by specifically selected food rations. The analysis of modern theoretical data of international and Russian scientific literature was conducted within the methodological approaches to organizing food for the population in conditions of chemical pollution of atmospheric air. We searched for scientific information in bibliographic and abstract databases. Besides, we presented the average long-term data on (1) the content of benzene and phenol in the atmospheric air and blood in children living under conditions of high chemical aerogenic load with these substances; (2) the state of the antioxidant and conjugation-elimination functions of the benzene biotransformation system; (3) the assessment of the secretion of proteolytic digestive enzymes; and (4) the state of liver cells and excretory-concentration function of the biliary tract. There are examples of food products, the systematic inclusion of which in the diet accelerates the modification and elimination of chemicals; moreover, it has a membrane-stabilizing, hepatoprotective, and antioxidant effect. Acceleration of biotransformation and elimination of toxic substances can be done by including food products with a high content of fiber and pectins in the diet. The acceleration of the metabolism of toxic substances can be carried out by including in the diet foods with a high content of fiber and pectins, polyunsaturated fatty acids, and antioxidant vitamins. The importance of the availability of special diets for all groups of the population living in industrially developed regions under conditions of aerogenic chemical load, including aromatic hydrocarbons, is shown to minimize the negative impact of human-made chemicals and prevent diseases caused by an increased level of atmospheric air pollution.
Introduction. The extraction of potash ores is developing at a significant pace. The flotation method is the way to obtain potassium chloride using chemical reagents that have a toxic effect on the respiratory and nervous system, and liver. The complex long-term impact of occupation factors of the working environment with an increase in work experience leads to a rise in the prevalence of diseases of vital organs and systems. The aim of the study is to assess the change in individual biochemical indices of unfavorable responses on the part of the health of workers at a potassium ore processing enterprise, depending on the length of work experience. Materials and methods. The working conditions of workers were assessed, the content of some aldehydes, hexane, and heptane in biological media was investigated, and changes in many biochemical parameters were established. Results. The factors of the working environment in workers at the potassium ore processing enterprise are characterized by the simultaneous exposure to chemicals (potassium chloride, formaldehyde, propionic and butyric aldehydes, hexane and heptane), physical parameters (industrial noise, the microclimate of the working area, the severity of the labor process) and are assessed as harmful (class 3.1). During long-term labor activity (more than ten years), workers have an accumulation of hexane in the urine (1.4 times) and the increased associated content of norepinephrine in blood plasma (up to 1.3 times), not established in workers with up to ten years of work experience. Workers with ten years of work experience and noise with a level of intensity at workplaces exceeding 14.4 dBA showed an increase of 1.3-2.3 times in the level of homocysteine and lipoprotein, not established in workers with a work experience duration of fewer than ten years. No dependence on the service terms was found for changes in sensitization indices of the upper respiratory tract and hepatocytes’ cytolytic activity. Conclusion. The revealed changes in indices with an increase in the length of service require special attention for the early diagnosis of occupational diseases and the development of measures to prevent emerging changes in critical organs and systems.
Changes in homeostatic balance of the body, primarily at the cellular-molecular level, are a relevant research object in fundamental and applied studies. They can be eligible indicators for predicting negative effects under exposure to chemical risk factors. The aim of this study was to substantiate markers of a transformed plasma proteomic profile in children. These markers should have prognostic value and an evidence-based association with combined aerogenic exposure to metal oxides (copper and nickel oxides used as an example). We propose an innovative methodical approach based on plasma proteomic profiling that includes the following: identification of identical proteins and genes encoding their expression; quantification of indicators within the ‘identical protein – a chemical concentration in blood’ system; prediction of negative effects as per indicators of homeostasis destabilization at the cellular-molecular level under chronic aerogenic exposure to chemicals. The proposed algorithm was tested by comparing changed proteins and peptides identified in plasma proteomic profiles of children exposed simultaneously to nickel and copper oxides in ambient air in actual conditions and small rodents under experimental combined and isolated exposure to the analyzed chemicals in levels equal to real ones. Long-term aerogenic exposure simultaneously to copper and nickel oxides was established to create elevated nickel and copper levels in blood of exposed children substantiated as markers of exposure. They were up to 2.4 times higher against the same indicators in unexposed children and reference levels as well. The results of field observations were verified by elevated levels of the same chemicals in blood under experimental modelling of an equivalent combined exposure performed on biological models. APOBEC1 complement factor (the А1CF gene) was substantiated as an identical proteomic marker based on plasma proteomic profiling in experimental and field investigations. It has an evidence-based association with markers of exposure (nickel and copper simultaneously identified in blood). Lower expression of this protein under persistent combined aerogenic exposure to nickel and copper oxides makes it possible to predict such a negative effect as modification of low density lipoproteins with further induction of atherosclerotic changes in vessels, the latter being a risk factor of cardiovascular diseases.
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