The current investigation represented the first anatomical description of the buccal cavity of the grey gurnard Eutrigla gurnardus. For the achievement of this study, 10 heads of mature fish were used for SEM examinations. The morphological characteristic appearance of the buccal cavity has shown several adaptations in relation concerning its feeding habits. The median fissure of the upper lip divided the upper lip into two halves, this fissure appeared to be formed from many micro‐tubercles with numerous taste buds which aid in holding mucus secretion to the cell surface, help in mucus spread, and provide mechanical protection to the epithelium. Velum had two regions: median and peripheral region. The epithelium covering of the median region of the upper velum had dots‐like epithelial protrusion that carrying numerous taste buds, meanwhile, the epithelium covering of the lower velum not carried taste buds but instead carried numerous small scales‐like structures. The palate is divided into two semicircular regions by small region of microridges into the anterior and posterior region. The slightly bifid tongue had a median tubercle with numerous small taste buds on its dorsal surface. Concluded, these data were necessary to understand the adaptation of fish to its habitat and in developing a new and better method for fishing of this type of fish.
Over the past few decades, gene therapy has gained immense importance in medical research as a promising treatment strategy for diseases such as cancer, AIDS, Alzheimer’s disease, and many genetic disorders. When a gene needs to be delivered to a target cell inside the human body, it has to pass a large number of barriers through the extracellular and intracellular environment. This is why the delivery of naked genes and nucleic acids is highly unfavorable, and gene delivery requires suitable vectors that can carry the gene cargo to the target site and protect it from biological degradation. To date, medical research has come up with two types of gene delivery vectors, which are viral and nonviral vectors. The ability of viruses to protect transgenes from biological degradation and their capability to efficiently cross cellular barriers have allowed gene therapy research to develop new approaches utilizing viruses and their different genomes as vectors for gene delivery. Although viral vectors are very efficient, science has also come up with numerous nonviral systems based on cationic lipids, cationic polymers, and inorganic particles that provide sustainable gene expression without triggering unwanted inflammatory and immune reactions, and that are considered nontoxic. In this review, we discuss in detail the latest data available on all viral and nonviral vectors used in gene delivery. The mechanisms of viral and nonviral vector-based gene delivery are presented, and the advantages and disadvantages of all types of vectors are also given.
One of the most significant challenges of diabetes health care is diabetic foot ulcers (DFU). DFUs are more challenging to cure, and this is particularly true for people who already have a compromised immune system. Pathogenic bacteria and fungi are becoming more resistant to antibiotics, so they may be unable to fight microbial infections at the wound site with the antibiotics we have now. This article discusses the dressings, topical antibacterial treatment, medications and debridement techniques used for DFU and provides a deep discussion of DFU and its associated problems. English-language publications on DFU were gathered from many different databases, such as Scopus, Web of Science, Science Direct, Springer Nature, and Google Scholar. For the treatment of DFU, a multidisciplinary approach involving the use of diagnostic equipment, skills, and experience is required. Preventing amputations starts with patient education and the implementation of new categorization systems. The microbiota involved in DFU can be better understood using novel diagnostic techniques, such as the 16S-ribosomal DNA sequence in bacteria. This could be achieved by using new biological and molecular treatments that have been shown to help prevent infections, to control local inflammation, and to improve the healing process.
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