Derivatives of Inositol 2397Reaction with Ammonia.-/3-Sulfopropionic anhydride was added in small portions to a large excess of liquid ammonia. After removal of the ammonia by evaporation, the white crystalline material was warmed gently to 60°t o remove the last traces of ammonia and crystallized from 80% methanol. The crystallized product melted at 179°. It was identified as the ammonium salt of ß-sulfopropionamide by its reactions and analysis.
Anal.Caled, for C3H10C>4H2S (NH4+-03SCH2CH2-CONH2): N, 16.45. Found: N, 16.50. Reaction with Methyl Alcohol.-/3-Sulfopropionic anhydride was treated with a slight excess of anhydrous methanol and the excess then removed in a vacuum desiccator over phosphorus pentoxide. A crystalline highly hygroscopic material was obtained. The melting point of this substance was 73 °.
depending upon the amount of cobalt present. If cobalt be absent, the precipitate will be a pale green, and will remain so upon standing.It will, therefore, be evident that by this test, which is practically instantaneous and requires no manipulation, it is possible in one operation. carried on in a test-tube, to detect both elements, even if either element be in exceedingly small amount, in a great excess of the other, the test for cobalt being probably as delicate as any hitherto proposed (with the exception of \-ogel's test, outlined above, which requires the use of ammonium sulphocyanide, amyl alcohol and ether), while that for the detection of nickel is considerably more delicate than anything hitherto proposed for this purpose.For use in ordinary qualitative analysis in college laboratories where nickel-free cobalt salts are not supplied to students, the test may be modified in one of two ways in order to slightly decrease its delicacy. ( I ) T"ne students may be told that unless the change of color is retarded over a minute nickel may be regarded as absent, or ( 2 ) by using, instead of a gS sodium hydroxide solution, a IOX or I j K solution, when the delicacy is so decreased as to give practically no reaction for nickel in ordinary cobalt salt solutions. I desire to express my sincere thanks to Dr. J. F. Snell for the valuable advice he has rendered during the progress of this work. THE best method for the synthetical preparation of quinoline and its derivatives is that of Skraup,' which consists in heating an aromatic amine with glycerin, an aromatic nitro compound (usually nitrobenzene), and sulphuric acid. A quinoline ring is formed by the combining of the aromatic amine and the glycerin with loss of water and hydrogen. The nitro compound serves as an oxidizing agent, and is itself reduced to an amine from which quinolines are also formed, sometimes making mixtures that are difficult to separate.
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