Introduction
The depiction of features in discourse production promotes accurate diagnosis and helps to establish the therapeutic intervention in cognitive impairment and dementia. We aimed to identify alterations in the macrolinguistic aspects of discourse using a new computational tool.
Methods
Sixty individuals, aged 60 years and older, were distributed in three different groups: mild Alzheimer's disease (mAD), amnestic mild cognitive impairment, and healthy controls. A narrative created by individuals was analyzed through the Coh-Metrix-Dementia program, extracting the features of interest automatically.
Results
mAD showed worse overall performance compared to the other groups: less informative discourse, greater impairment in global coherence, greater modalization, and inferior narrative structure. It was not possible to discriminate between amnestic mild cognitive impairment and healthy controls.
Discussion
Our results are in line with the literature, verifying a pathological change in the macrostructure of discourse in mAD.
IntroductionVisuospatial processing is a fundamental aspect in human cognition, belonging
to a complex and intricate network. It is, in other words, one of the
building blocks of an individual's identity and behavior.ObjectiveTo allow an overall and updated review of visuospatial processing and its
related events, in light of new techniques and evidence, focusing on basic
concepts of higher cortical functions, its pathways and associated
systems.MethodsThe study was conducted based on the national and international databases
LILACS, MEDLINE, ScieLo and Pubmed; using the search word "visuospatial" in
combination with "pathway", "processing", "function", "fMRI" and
"attention".ResultsA total of 77 references deemed relevant for its historical, conceptual or
updated relevance were selected out of 1222 retrieved; including English,
Spanish and Portuguese languages. A critical review was carried out and many
new aspects discussed.ConclusionA new functioning and construction of sight processing is being shaped,
culminating now in a model based on dynamic and integrated interactions
between pathways and systems.
Objective:To compare results of positron emission tomography (PET) with carbon-11-labeled Pittsburgh compound B (11C-PIB) obtained with cerebellar or global brain uptake for voxel intensity normalization, describe the cortical sites with highest tracer uptake in subjects with mild Alzheimer’s disease (AD), and explore possible group differences in 11C-PIB binding to white matter.Methods:
11C-PIB PET scans were acquired from subjects with AD (n=17) and healthy elderly controls (n=19). Voxel-based analysis was performed with statistical parametric mapping (SPM).Results:Cerebellar normalization showed higher 11C-PIB uptake in the AD group relative to controls throughout the cerebral cortex, involving the lateral temporal, orbitofrontal, and superior parietal cortices. With global uptake normalization, greatest cortical binding was detected in the orbitofrontal cortex; decreased 11C-PIB uptake in white matter was found in the posterior hippocampal region, corpus callosum, pons, and internal capsule.Conclusion:The present case-control voxelwise 11C-PIB PET comparison highlighted the regional distribution of amyloid deposition in the cerebral cortex of mildly demented AD patients. Tracer uptake was highest in the orbitofrontal cortex. Decreased 11C-PIB uptake in white-matter regions in this patient population may be a marker of white-matter damage in AD.
Descargas ictais, periódicas ou rítmicas induzidas por estímulos (SIRPIDs) associadas a crises epilépticas na neurotoxicidade por cefepime Figure). Cefepime was discontinued. Subsequent EEG demonstrated only slowed background (SB).
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