Rev Rev Rev Rev Rev Bras Enferm, Brasília 200 Bras Enferm, Brasília 200 Bras Enferm, Brasília 200 Bras Enferm, Brasília 200 Bras Enferm, Brasília 2009 9 9 9 9 jan-fev; jan-fev; jan-fev; jan-fev; jan-fev; 6 6 6 6 62 2 2 2 2(((((1 1 1 1 1):):):):): 119-24 119-24 119-24 119-24 119-24.. .. . I I I I RESUMO RESUMO RESUMO RESUMO RESUMO A SIDA coloca questões sociais, humanitárias e jurídicas cruciais, e ameaça alterar seriamente fundamentos da estrutura social de tolerância e entendimento que sustém a vida das nossas sociedades. A partir de uma contextualização dos aspectos clínicos e epidemiológicos do VIH/SIDA, este artigo de revisão bibliográfica faz uma abordagem da vivência psicológica e das implicações da infecção com o Vírus da Imunodeficiência Humana Adquirida na mulher grávida. ABSTRACT ABSTRACT ABSTRACT ABSTRACT ABSTRACT AIDS raises a social issue, humanitarian, legal, and threatens to change the social structure founding of tolerance and understanding, that sustains the life of our societies. From a clinical and epidemiological background of HIV/AIDS, this article of literature review makes an approach about psychological experience and implication of the Human Immunodeficiency Virus infection in pregnant woman. Descriptors: Descriptors: Descriptors: Descriptors: Descriptors: HIV; AIDS; Women's health; Pregnancy. RESUMEN RESUMEN RESUMEN RESUMEN RESUMEN SIDA plantea cuestiones sociales, humanitarias y jurídicas fundamentales, y amenaza cambiar gravemente motivos de la estructura social de tolerancia y comprensión, que sustenta la vida de nuestra sociedad. Desde una contextualización de los aspectos clínico y epidemiológicos del VIH / SIDA, en este artículo de revisión bibliográfica se hace un enfoque acerca de la v psicológica y la implicación de la infección por el Virus de Inmunodeficiencia Humana Adquirida en la mujer embarazada. Cor Cor Cor Cor Correspondência: respondência: respondência: respondência: respondência: Sílvia do Rosário Piteira Natário de Lourenço. Rua Dr. José Brás, 16, 1º Distrito CEP 2910-559. Setúbal, Portugal. 120 120 120 120 120 Rev Bras Enferm, Brasília 200 Rev Bras Enferm, Brasília 200 Rev Bras Enferm, Brasília 200 Rev Bras Enferm, Brasília 200 Rev Bras Enferm, Brasília 2009 9 9 9 9 jan-fev jan-fev jan-fev jan-fev jan-fev; 6 ; 6 ; 6 ; 6 ; 62 2 2 2 2(((((1 1 1

No abstract

No abstract

No abstract

FLOT regimen became the standard perioperative treatment in several centers around the world for esophagogastric tumors despite concerns about toxicity. In addition, FLOT has never been compared with other docetaxel-based regimens. To address this question, we conducted a systematic review of PubMed, Embase and Web of Science including prospective or retrospective studies of docetaxel based perioperative regimen in gastric and esophagogastric tumors. Data regarding chemotherapy regimens, efficacy and toxicity were extracted. Outcomes were compared using a random effects model. Of 548 abstracts, 16 were considered eligible. Comparing the studies with meta-analysis we can see that the regimens are similar in terms of pathological complete response, resection rate, progression free survival and overall survival in one year, without significant heterogeneity. The meta-regression of docetaxel dose failed to show any association with dose ranging between 120–450 mg/m². Regarding the toxicity of the regimens it is noted that the regimens are quite toxic (up to 50–70% of grade 3–4 neutropenia). The results of this meta-analysis with a combined sample size of more than 1,000 patients suggest that docetaxel perioperative regimens are equivalent in outcomes. Prospective trials addressing modified regimens should be performed to provide less toxic strategies and be applicable to all patients.

The real impact of specific sites of metastasis on prognosis of metastatic pancreatic cancer (MPC) is unknown. To evaluate the association of specific metastatic sites and survival outcomes in MPC a systematic literature review was performed including prospective randomized trials of systemic treatments in metastatic pancreatic cancer indexed in PubMed, Embase and Web of Science. Data regarding systemic treatment regimens, progression free survival and overall survival were extracted. The outcomes were compared using a random effects model. The index I2 and the graphs of funnel plot were used for the interpretation of the data. Of 1,052 abstracts, 7 randomized trials were considered eligible with a combined sample size of 2,975 MPC patients. Combining the studies with meta-analysis, we could see that patients with liver metastasis had a HR for death of 1.53 with 95% CI of 1.15 to 2.02 (p-value 0.003) and HR for risk of progression of 1.96 with 95% CI of 1.28 to 2.99 (p-value 0.002), without significant heterogeneity. Having two or more sites of metastasis comparing to one site did not have impact on overall survival; RR of 1.05 with 95% CI 0.91 to 1.23 (p-value 0.493). In conclusion, liver metastasis confers worse outcomes among patients with MPC. Apparently, multiple metastatic sites do not present worse prognosis when compared with only one organ involved, therefore, demonstrating the severity of this disease. Prospective studies evaluating other treatments are necessary to address the impact of local treatments in liver metastasis in MPC. OPEN ACCESSCitation: Usón PLS, Junior, Tolentino FD'AvilaS, Santos VM, Rother ET, Maluf FC (2020) The impact of metastatic sites in advanced pancreatic adenocarcinoma, systematic review and metaanalysis of prospective randomized studies. PLoS ONE 15(3): e0230060. https://doi.org/10.

No abstract

No abstract