Pentoxifylline administration reduced the systemic inflammatory response, the pancreatic histological lesion and renal dysfunction in pancreatic I-R injury and may be a useful tool in pancreas and kidney transplantation.

BACKGROUND: Liver metastases from colorectal cancer are an important public health problem due to the increasing incidence of colorectal cancer worldwide. Synchronous colorectal liver metastasis has been associated with worse survival, but this prognosis is controversial. OBJECTIVE: The objective of this study was to evaluate the recurrence-free survival and overall survival between groups of patients with metachronous and synchronous colorectal hepatic metastasis. METHODS: This was a retrospective analysis of medical records of patients with colorectal liver metastases seen from 2013 to 2016, divided into a metachronous and a synchronous group. The Cox regression model and the Kaplan-Meier method with log-rank test were used to compare survival between groups. RESULTS: The mean recurrence-free survival was 9.75 months and 50% at 1 year in the metachronous group and 19.73 months and 63.3% at 1 year in the synchronous group. The mean overall survival was 20.00 months and 6.2% at 3 years in the metachronous group and 30.39 months and 31.6% at 3 years in the synchronous group. Patients with metachronous hepatic metastasis presented worse overall survival in multivariate analysis. The use of biological drugs combined with chemotherapy was related to the best overall survival prognosis. CONCLUSION: Metachronous colorectal hepatic metastasis was associated with a worse prognosis for overall survival. There was no difference in recurrence-free survival between metachronous and synchronous metastases.

Myeloid-derived suppressor cells (MDSC) have been recently observed in the liver parenchyma of tumor-bearing animals. Kupffer cells represent the first line of defense against tumor cells in the liver. The present study investigates the function of various MDSC subsets and their interaction with Kupffer cells.RIL-175 hepatocellular carcinoma cells were injected into the liver of C57BL/6 mice. Three MDSC subsets were sorted. Their suppressive activities were assessed against T cells and primary isolated Kupffer cells.On day 21, MDSC increased in the spleen and in the underlying liver parenchyma of HCC-bearing mice (vs sham-operated animals, p < 0.02). Three CD11b + cell populations were identified and sorted. They expressed different level of MDSC-specific surface markers: Ly6G high cells, Gr1 high cells and Ly6C low cells, and might be considered as MDSC as they suppressed antigen-specific T cell proliferation. The coculture of primary isolated Kupffer cells with the three MDSC subsets showed a decrease in CCL2 and IL-18 secretion and an increase in IL-10 secretion (p < 0.05). Kupffer cells in coculture had also an increased expression of PD-L1 (p < 0.01).These data demonstrate the existence of three MDSC subsets in HCC-bearing animals. These cells alter Kupffer cell function, and may decrease the migration and activation of anti-cancer effector cells in the liver.

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Bismuth type 3 was the commonest ( 14) type of injury/ stricture followed by type 2 (3) and type 1 (2). There was 1 mortality following surgery due to bile leak followed by severe sepsis. Remaining 18 patients had excellent postoperative outcome without significant morbid.

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