Effects of intravenous administration of pentoxifylline in pancreatic ischaemia–reperfusion injury

Campion, Edmond Raymond Le; Jukemura, José; Coelho, Ana Maria M.; Patzina, Rosely Antunes; D’Albuquerque, Luiz Augusto Carneiro

doi:10.1111/hpb.12013

Cited by 10 publications

(5 citation statements)

References 35 publications

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“…The histologic score was significantly lower in pentoxifylline-treated animals, denoting less severe pancreatic histologic damage. Pentoxifylline administration in this study reduced the systemic inflammatory response, the pancreatic histological lesion and renal dysfunction in pancreatic I-R injury 69 . The efficacy of blood purification methods including hemofiltration or hemodialysis in the treatment of underlying SAP by ameliorating the systemic inflammatory response has been investigated in several studies.…”

Section: Treatment Of Underlying Disease (Sap)mentioning

confidence: 50%

Acute kidney injury following acute pancreatitis: A review

Petejová¹,

Martínek²

2013

BIOMED PAP

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Backround. Acute kidney injury (AKI) is a common serious complication of severe acute pancreatitis (SAP) and an important marker of morbidity and mortality in critically ill septic patients. AKI due to severe acute pancreatitis can be the result of hypoxemia, release of pancreatic amylase from the injured pancreas with impairment of renal microcirculation, decrease in renal perfusion pressure due to abdominal compartment syndrome, intraabdominal hypertension or hypovolemia. Endotoxins and reactive oxygen species (ROS) also play an important role in the pathophysiology of SAP and AKI. Knowledge of the pathophysiology and diagnosis of AKI following SAP might improve the therapeutic outcome of critically ill patients. Methods and Results. An overview of the pathophysiology, diagnosis and potential treatment options based on a literature search of clinical human and experimental studies from 1987 to 2013. Conclusions. Early recognition of AKI and SAP in order to prevent severe complication like septic shock, intraabdominal hypertension or abdominal compartment syndrome leading to multiple organ dysfunction syndrome is a crucial tool of therapeutic measures in intensive care.

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Section: Treatment Of Underlying Disease (Sap)mentioning

confidence: 50%

Acute kidney injury following acute pancreatitis: A review

Petejová¹,

Martínek²

2013

BIOMED PAP

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“…22 The present experimental model caused acute pancreatitis secondary to ischemia, as in the study of Le Campion et al 12 Indeed, significant high serum levels of amylase and lipase were evident in groups 2 and 3 when compared with the sham group ( Table 1). The probable reason for the elevation of these enzymes was the increase of the reactive oxygen species damage caused by the pancreatic IR injury.…”

Section: Discussionmentioning

confidence: 56%

The Effects of Profound Hypothermia on Pancreas Ischemic Injury

Rocha-Santos¹,

Ferro²,

Pantanali³

et al. 2014

Pancreas

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“…The transcription factor NF-κB is frequently found in inflamed colonic mucosa in patients with IBD, and activation of NF-κB is deeply associated with the induction of TNF-α [ 40 ]. Recent studies have demonstrated that PTX reduces the expression of TNF-α by inhibiting the NF-κB activity in various organs [ 41 , 42 ]. In the present study, the expression of TNF-α and NF-κB was inhibited in the colorectum of the PTX-treated groups.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of pentoxifylline on inflammation-related tumorigenesis in rat colon

et al. 2018

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Chronic inflammation in the colorectum increases the risk of colorectal cancer development. Pentoxifylline, a medicine used for improving the circulation, has been reported to inhibit TNF-α production and to ameliorate inflammatory bowel disease and non-alcoholic steatohepatitis. In this study, we investigated the effects of pentoxifylline on inflammation-related colon tumorigenesis in a rodent model using Kyoto APC delta rats, which have APC mutation and are susceptible to colon carcinogenesis. Male Kyoto APC delta rats were treated with azoxymethane and dextran sodium sulfate, and were subsequently administered water, with or without pentoxifylline. At the end of the experiment, the development of colorectal tumor was significantly inhibited in the pentoxifylline group. The pentoxifylline treatment also lowered the levels of oxidative stress markers and mRNAs of pro-inflammatory cytokines, including TNF-α and IL-6, in the colon mucosa. The PCNA labeling index and the inflammation score were also decreased in the colon of rats in the pentoxifylline -treated group. We also used an endoscopy to observe the tumor progression and inflammation in the colon of rats, revealing that inflammation grade was significantly lower in pentoxifylline-treated group at several points during the experiment. These findings suggest that pentoxifylline treatment might be useful for chemoprevention of inflammation-related colon cancer.

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Effects of intravenous administration of pentoxifylline in pancreatic ischaemia–reperfusion injury

Abstract: Pentoxifylline administration reduced the systemic inflammatory response, the pancreatic histological lesion and renal dysfunction in pancreatic I-R injury and may be a useful tool in pancreas and kidney transplantation.

Cited by 10 publications

References 35 publications

Acute kidney injury following acute pancreatitis: A review

Acute kidney injury following acute pancreatitis: A review

The Effects of Profound Hypothermia on Pancreas Ischemic Injury

Inhibitory effects of pentoxifylline on inflammation-related tumorigenesis in rat colon

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