Background: Childhood obesity is a growing and significant problem worldwide. Asprosin is a novel adipokine that is significantly associated with glucose and insulin production in the liver during fasting. In the present study, we aimed to demonstrate whether there would be differences between obese, overweight, and normal weight children in terms of serum asprosin levels. Methods: Forty-four children with obesity, 54 overweight children, and 60 normal weight children were compared in terms of serum asprosin levels and other anthropometric, biochemical, and hormonal parameters that are associated with being overweight and with obesity. Results: Serum asprosin levels were found to be significantly different between groups: 70.903 AE 17.49 ng/mL, 79.744 AE 29.54 ng/mL, and 106.293 AE 122.69 ng/mL in normal weight, overweight, and obese children respectively. Post-hoc analysis revealed that the asprosin level was significantly higher in obese children compared with normal weight children (P = 0.009). Additionally, asprosin was found to be a predictor of obesity in multiple regression analysis. Conclusion: Our study is the first to demonstrate increased levels of asprosin in obese children compared with normal weight children. Further studies are needed to demonstrate the role of asprosin in the etiology of childhood obesity, as well as other diseases that might be associated with effects of asprosin.
Although the exact pathophysiology of critical illness polyneuropathy (CIP) is still unknown, there are several hypotheses, some of which are increased inflammation and oxidative stress. We used rodent sepsis model in which we induced sepsis through cecal ligation followed by cecal puncture. We then administered ascorbic acid (AA) and evaluated outcomes. The levels of malondialdehyde (MDA), tumor necrosis factor α (TNF-α), interleukins (IL)-6 in the plasma, and heat shock protein-70 (HSP-70) levels in the sciatic nerve were measured, and also electromyography analyses were performed. While plasma MDA, TNF-α, and IL-6 levels were decreased significantly with AA treatment, sciatic nerve levels of HSP-70 were significantly elevated in the AA group. A significant increase in compound muscle action potential (CMAP) amplitude and a significant decrease in CMAP latency were detected in the AA group. We observed healing effects of AA on a rat model of CIP and these effects seem to be related to its anti-inflammatory and antioxidant properties.
Objective: In this study was to evaluate the frequency of functional gastrointestinal disorders (FGIDs) including functional constipation, functional diarrhea and infantile colic, and the relationship between these diseases and nutritional practices. Material and Methods: The study included 400 patients (4-24 months old) that applied to the pediatric health and diseases outpatient clinic or emergency clinic between 15 February 2019 and 31 May 2019. Patients without chronic diseases and who did not receive vitamin or appetite-enhancing medications other than vitamin D and iron were included in the study. The socio-demographic and nutritional characteristics of the patients were evaluated through a questionnaire. Patients suspected of having infantile colic, functional diarrhea and functional constipation were evaluated with the ROME-IV diagnostic criteria. Results: Among 400 patients, 24.2% (n = 97) had infantile colic, 5.8% (n = 23) had functional constipation, and 2.5% (n = 10) had functional diarrhea. In those with infantile colic or functional constipation, cesarean delivery rate was found to be higher than those without (p = 0.008 and p = 0.032, respectively). The frequency of infantile colic was found to be lower in recipients of vitamin D prophylaxis (p = 0.032), and vitamin D use frequency was lower in those with functional constipation (p = 0.001). Conclusion: In our study, infantile colic was the most common FGID seen in infants, while functional constipation was the second. A higher rate of carbohydrate-rich nutrition was identified in patients with functional diarrhea.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.