The frequency of and factors affecting functional gastrointestinal disorders in infants that presented to tertiary care hospitals

Beşer, Ömer Faruk; Çokuğraş, Fügen; Doğan, Güzide; Akgün, Özlem; Elevli, Murat; Yılmazbaş, Pınar; Ocal, Meric; Bayrak, Nevzat Aykut; Sezer, Rabia Gönül; Bozaykut, Abdülkadir; Çeltik, Coşkun; Polat, Esra; Gerenli, Nelgin; Bozlak, Serdar; Civan, Hasret Ayyıldız; Sağlam, Neslihan Özkul; Hatipoğlu, Sinan; Özgürhan, Gamze; Silistre, Eda Sünnetçi; Solmaz, Burcu; Kutluk, Günsel; Genç, Hamide Sevinç; Önal, Hasan; Usta, Ayşe; Urgancı, Nafiye; Şahin, Ayşe; Cam, Sebahat; Yıldırım, Şükran; Yildirim, Asilay; Vandenplas, Yvan

doi:10.1007/s00431-021-04059-2

Cited by 19 publications

(31 citation statements)

References 22 publications

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“…According to literature data, it can be estimated that about 50% of infants present with a combination of FGIDs (range 4-77%) [1][2][3]8]. It might be difficult for the health care provider to discover the triggering mechanism.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Functional gastro-intestinal disorders (FGIDs) occur in more than 25% of all infants and are a frequent reason for parents to consult a health care provider [1][2][3][4]. Regurgitation, infantile colic and functional constipation are the most common FGIDs [1][2][3][4]. Although FGIDs have per definition no identifiable underlying organic cause [5], infants with a FGID and their families display a reduced quality of life (QoL) and consult more often than asymptomatic controls [6].…”

Section: Introductionmentioning

confidence: 99%

“…FGIDs are a frequent reason for hospitalization, parental anxiety and depression, loss of parental working days with relevant social consequences and/or administration of drugs [2,7]. Many infants present with a combination of several FGIDs, although the reported range varies from 4.2% to 77% [1][2][3]8].…”

Section: Introductionmentioning

confidence: 99%

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An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders

Vandenplas

Gerlier²,

Caekelbergh³

et al. 2021

Nutrients

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Functional gastro-intestinal disorders (FGIDs) impair the quality of life of many infants and their families. A formula with partial whey hydrolysate, starch, high magnesium content, prebiotic fructo-oligosaccharide and galacto-oligosaccharide and the probiotic Lactobacillus reuteri DSM 17938 was given during two weeks to 196 infants with at least two FGIDs. The efficacy was evaluated with the Cow Milk-associated Symptom Score (CoMiSS®) and quality of life with the QUALIN score. The formula was shown to decrease FGIDs within three days (decrease of CoMiSS −1.29 (3.15) (mean (SD), p < 0.0001) followed by an improvement of quality of life after seven days (increase QUALIN +1.4 (7.8); p: 0.008). Constipation decreased from 18.8% to 6.5% within three days. In combination with reassurance and guidance, the nutritional intervention was shown to be effective in infants with FGIDS in real-life circumstances.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders

Vandenplas

Gerlier²,

Caekelbergh³

et al. 2021

Nutrients

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“…For example, the definition of wheezing is reflected in the differences seen through estimating the prevalence of asthma (25,26). These differences could also explain a lower prevalence of FGIDs consistently reported by healthcare professionals compared to that reported by parents (13,18).…”

Section: Discussionmentioning

confidence: 99%

A Narrative Review on the Update in the Prevalence of Infantile Colic, Regurgitation, and Constipation in Young Children: Implications of the ROME IV Criteria

Muhardi¹,

Hasosah

et al. 2022

Front. Pediatr.

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Regurgitation, colic, and constipation are frequently reported Functional Gastrointestinal Disorders (FGIDs) in the first few years of life. In 2016, the diagnostic criteria for FGIDs were changed from ROME III to ROME IV. This review assesses the prevalence of the most frequent FGIDs (colic, regurgitation and constipation) among children aged 0–5 years after the introduction of the later criteria. Articles published from January 1, 2016 to May 1, 2021 were retrieved from PubMed and Google Scholar using relevant keywords. A total of 12 articles were further analyzed based on the inclusion and exclusion criteria. This review consists of two studies (17%) from the Middle East, three (25%) from Asia, two (17%) from the USA, three (25%) from Europe, and one (8%) from Africa. Three studies (25%) were based on data obtained from healthcare professionals, while the rest were parent or caregiver reports. About half of the retrieved studies used the ROME IV criteria. Among infants aged 0–6 months, the reported prevalence of colic ranged between 10–15%, whilst that of regurgitation was 33.9%, and constipation was 1.5%. Among infants aged 0–12 months, the reported prevalence of regurgitation and constipation were 3.4–25.9% and 1.3–17.7%, respectively. The reported prevalence of constipation was 1.3–26% among children aged 13–48 months and 13% among children aged 4–18 years. Despite the large variations due to differences in diagnostic criteria, study respondents and age group, the prevalence of infantile colic was higher, while that for infantile regurgitation and constipation were similar using the ROME IV or III criteria.

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Functional Gastrointestinal Disorders in Infants and Toddlers

Salvatore

Vandenplas

2022

Pediatric Neurogastroenterology

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The frequency of and factors affecting functional gastrointestinal disorders in infants that presented to tertiary care hospitals

Cited by 19 publications

References 22 publications

An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders

An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders

A Narrative Review on the Update in the Prevalence of Infantile Colic, Regurgitation, and Constipation in Young Children: Implications of the ROME IV Criteria

Functional Gastrointestinal Disorders in Infants and Toddlers

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