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and routes form the subject matter of volume 22 of this comprehensive handbook of biochemistry, which, SO to speak, gives a chapter by chapter account of the foundations of a "submolecular biology". In the first chapter A . and B. Pufltnan describe the general ideas and methods of quantum biochemistry, which is concerned with the quantum mechanical investigation of the electronic structure of biologically important molecules. The achievements and predictions realizable by means of this theoretical treatment are illustrated by a number of examples. B. Grabe's new interpretation of the "energy-rich bond" is, of course, not mentioned since oniy the literature up to the beginning of 1966 is referred to. Attempting to force such a rapidly developing science into a relatively slowly appearing compendium clearly has its limitations.The mechanisms of energy transfer are dealt with by Th. Forster in a short section devoted to the problem of transfer of free energy between various cell components. A lucid account is given of the theoretical and the experimental approaches t o the resolution of this problem which, of course, still rely largely on the use of models. Charge transfer

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tes ( 5 ) entstehen. Daneben ist die Bildung von (6) sowie (8) -(II) durch elektrophilen Angriff von ( 4 ) an (1) denkbar. aus der OH-Gruppe erwartet. Offensichtlich wird in den ubergangszustanden der beiden konkurrierenden Reaktionen nur ein Bruchteil der Differenz aus den Bindungst i~n [~] , da man von alternativen Vorstufen ausgeht und protonische Solventien benutzen kann. Wegen der gerin-Eingegangen am 1. September 1971 [Z 521 a] geren Anionreaktivitat der Borate sollte die Verwendung NO,, COOR oder SO,R moglich sein.