This nomogram is helpful in the prediction of febrile neutropenia after chemotherapy in patients with lung, breast, and colon cancer. Usage of this nomogram may help decrease the morbidity and mortality associated with febrile neutropenia and deserves further validation.
Background: Pain is one of the most terrifying symptoms for cancer patients. Although most patients with cancer pain need opioids, complete relief of pain is hard to achieve. This study investigated the factors influencing persistent pain-free survival (PPFS) and opioid efficiency. Materials and Methods: A prospective study was conducted on 100 patients with cancer pain, hospitalized at the medical oncology clinic of Akdeniz University. Patient records were collected including patient demographics, the disease, treatment characteristics, and details of opioid usage. Pain intensity was measured using a patient self-reported visual analogue scale (VAS). The area under the curve (AUC) reflecting the pain load was calculated from daily VAS tables. PPFS, the primary measure of opioid efficacy, was described as the duration for which a patient reported a greater than or equal to two-point decline in their VAS for pain. Predictors of opioid efficacy were analysed using a multivariate analysis.
Girişİnsan herpesvirusları arasında yer alan herpes simpleks virusu (HSV) 1 toplumda yaygındır ve aktif veya latent infeksiyonlara neden olmaktadır. Primer infeksiyon sırasında sinir sistemine yerleşerek kronik latent infeksiyon oluşturan virus zaman zaman aktive olarak, cilt veya mukozalarda tekrarlayan lezyonlara neden olmaktadır. Virus reaktivasyonunu yüksek ateş, ultraviyole ışınlar, menstrüasyon veya stres stimüle edebilir. HSV 1 genellikle ağız çevresi ve yüzde klasik veziküler ve/veya ülseratif lezyonlar yaparak herpetik stomatit, orolabiyal herpes ve keratit gibi lokal infeksiyonlara neden olur; ayrıca sporadik viral ensefalitin en sık nedenidir (1). İn-fekte kişilerle temas, ortak eşyaların kullanımı, otoinokü-lasyon veya cinsel temas yoluyla bulaşabilir; farklı vücut alanlarında infeksiyonlara neden olabilir (2,3).Metotreksat, sinoviyal hücre proliferasyonu ve inflamasyonunun eklemlerde destrüksiyon yapmasıyla karakterize, otoimmün sistemik bir hastalık olan romatoid artrit tedavisinde ilk tercih edilen ilaçlardan biridir (4). Metotreksat bir dihidrofolat redüktaz enzim inhibitörüdür ve bu nedenle timidilat yapımını ve DNA sentezini azaltarak hızlı çoğalma özelliği olan dokuları özellikle kemik iliğini, oral mukoza ve gastrointestinal sistemi etkiler (5).Bu yazıda ateş, boğaz ağrısı, ağız çevresinde belirgin olan ve tüm vücuda yayılan döküntüler nedeniyle has-
AbstractHerpes simplex virus (HSV) 1 commonly causes local skin infection around the mouth and face. However, infection may become widespread and can be more severe especially in people with immunodeficiency. Methotrexate is an antiproliferative and antifolate drug which is used successfully in the treatment of chronic inflammatory diseases such as rheumatoid arthritis. On the other hand, it is associated with severe toxicity and side effects. In this article, a 53-year-old patient who applied to our hospital due to the rashes all over the body and apparent around the mouth, beside fever is presented. The patient who has been receiving methotrexate treatment because of rheumatoid arthritis had kidney transplantation five years ago. HSV 1 viremia was detected in the patient and the symptoms improved quickly with acyclovir. Klimik Dergisi 2016; 29(1): 43-6.
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