PSMD is a new, fully automated, and robust imaging marker for SVD. PSMD can easily be applied to large samples and may be of great utility for both research studies and clinical use. Ann Neurol 2016;80:581-592.

In daily social interactions, we need to be able to navigate efficiently through our social environment. According to Dennett (1971), explaining and predicting others’ behavior with reference to mental states (adopting the intentional stance) allows efficient social interaction. Today we also routinely interact with artificial agents: from Apple’s Siri to GPS navigation systems. In the near future, we might start casually interacting with robots. This paper addresses the question of whether adopting the intentional stance can also occur with respect to artificial agents. We propose a new tool to explore if people adopt the intentional stance toward an artificial agent (humanoid robot). The tool consists in a questionnaire that probes participants’ stance by requiring them to choose the likelihood of an explanation (mentalistic vs. mechanistic) of a behavior of a robot iCub depicted in a naturalistic scenario (a sequence of photographs). The results of the first study conducted with this questionnaire showed that although the explanations were somewhat biased toward the mechanistic stance, a substantial number of mentalistic explanations were also given. This suggests that it is possible to induce adoption of the intentional stance toward artificial agents, at least in some contexts.

Diffusion alterations and clinical status in SVD are largely determined by extracellular fluid increase rather than alterations of white matter fiber organization.

Background and PurposeNeurofilament light chain (NfL) is a blood marker for neuroaxonal damage. We assessed the association between serum NfL and cerebral small vessel disease (SVD), which is highly prevalent in elderly individuals and a major cause of stroke and vascular cognitive impairment. MethodsUsing a cross-sectional design, we studied 53 and 439 patients with genetically defined SVD (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy [CADASIL]) and sporadic SVD, respectively, as well as 93 healthy controls. Serum NfL was measured by an ultrasensitive single-molecule array assay. We quantified magnetic resonance imaging (MRI) markers of SVD, i.e., white matter hyperintensity volume, lacune volume, brain volume, microbleed count, and mean diffusivity obtained from diffusion tensor imaging. Clinical characterization included neuropsychological testing in both SVD samples. CADASIL patients were further characterized for focal neurological deficits (National Institutes of Health stroke scale [NIHSS]) and disability (modified Rankin scale [mRS]). ResultsSerum NfL levels were elevated in both SVD samples (P<1e-05 compared with controls) and associated with all SVD MRI markers. The strongest association was found for mean diffusivity (CADASIL, R2=0.52, P=1.2e-09; sporadic SVD, R2=0.21, P<1e-15). Serum NfL levels were independently related to processing speed performance (CADASIL, R2=0.27, P=7.6e-05; sporadic SVD, R2=0.06, P=4.8e-08), focal neurological symptoms (CADASIL, NIHSS, P=4.2e-05) and disability (CADASIL, mRS, P=3.0e-06). ConclusionsWe found serum NfL levels to be associated with both imaging and clinical features of SVD. Serum NfL might complement MRI markers in assessing SVD burden. Importantly, SVD needs to be considered when interpreting serum NfL levels in the context of other age-related diseases.

The described auditory BCI system may help end-users to communicate independently of gaze control with their environment.

Cognitive reserve (CR) shows protective effects in Alzheimer's disease (AD) and reduces the risk of dementia. Despite the clinical significance of CR, a clinically useful diagnostic biomarker of brain changes underlying CR in AD is not available yet. Our aim was to develop a fully-automated approach applied to fMRI to produce a biomarker associated with CR in subjects at increased risk of AD. We computed resting-state global functional connectivity (GFC), i.e. the average connectivity strength, for each voxel within the cognitive control network, which may sustain CR due to its central role in higher cognitive function. In a training sample including 43 mild cognitive impairment (MCI) subjects and 24 healthy controls (HC), we found that MCI subjects with high CR (> median of years of education, CR+) showed increased frequency of high GFC values compared to MCI-CR- and HC. A summary index capturing such a surplus frequency of high GFC was computed (called GFC reserve (GFC-R) index). GFC-R discriminated MCI-CR+ vs. MCI-CR-, with the area under the ROC = 0.84. Cross-validation in an independently recruited test sample of 23 MCI subjects showed that higher levels of the GFC-R index predicted higher years of education and an alternative questionnaire-based proxy of CR, controlled for memory performance, gray matter of the cognitive control network, white matter hyperintensities, age, and gender. In conclusion, the GFC-R index that captures GFC changes within the cognitive control network provides a biomarker candidate of functional brain changes of CR in patients at increased risk of AD.

In daily social interactions, we need to be able to navigate efficiently through our social environment. According to Dennett (1971), explaining and predicting others’ behaviour with reference to mental states (adopting the intentional stance) allows efficient social interaction. Today we also routinely interact with artificial agents: from Apple’s Siri to GPS navigation systems. In the near future, we might start casually interacting with robots. This paper addresses the question of whether adopting the intentional stance can also occur with respect to artificial agents. We propose a new tool to explore if people adopt the intentional stance towards an artificial agent (humanoid robot). The tool consists in a questionnaire that probes participants’ stance by requiring them to choose the likelihood of an explanation (mentalistic vs. mechanistic) of a behaviour of a robot iCub depicted in a naturalistic scenario (a sequence of photographs). The results of the first study conducted with this questionnaire showed that although the explanations were somewhat biased towards the mechanistic stance, a substantial number of mentalistic explanations were also given. This suggests that it is possible to induce adoption of the intentional stance towards artificial agents, at least in some contexts.

cSS was absent in CADASIL, whereas other small vessel disease imaging features were similar to CAA patients with cSS. Our findings suggest that cSS in combination with other small vessel disease imaging markers is highly indicative of CAA.