[1] We combine estimates of the surface mass balance, SMB, of the Greenland ice sheet for years 1958 to 2007 with measurements of the temporal variability in ice discharge, D, to deduce the total ice sheet mass balance. During that time period, we find a robust correlation (R 2 = 0.83) between anomalies in SMB and in D, which we use to reconstruct a continuous series of total ice sheet mass balance. We find that the ice sheet was losing 110 ± 70 Gt/yr in the 1960s, 30 ± 50 Gt/yr or near balance in the 1970s-1980s, and 97 ± 47 Gt/yr in 1996 increasing rapidly to 267 ± 38 Gt/yr in 2007. Multi-year variations in ice discharge, themselves related to variations in SMB, cause 60 ± 20% more variation in total mass balance than SMB, and therefore dominate the ice sheet mass budget. Citation: Rignot, E., J.

The Biomolecular Interaction Network Database (BIND) (http://bind.ca) archives biomolecular interaction, reaction, complex and pathway information. Our aim is to curate the details about molecular interactions that arise from published experimental research and to provide this information, as well as tools to enable data analysis, freely to researchers worldwide. BIND data are curated into a comprehensive machinereadable archive of computable information and provides users with methods to discover interactions and molecular mechanisms. BIND has worked to develop new methods for visualization that amplify the underlying annotation of genes and proteins to facilitate the study of molecular interaction networks. BIND has maintained an open database policy since its inception in 1999. Data growth has proceeded at a tremendous rate, approaching over 100 000 records. New services provided include a new BIND Query and Submission interface, a Standard Object Access Protocol service and the Small Molecule Interaction Database (http://smid.blueprint.org) that allows users to determine probable small molecule binding sites of new sequences and examine conserved binding residues. INTRODUCTIONIn light of the vast scientific resources made available through genomics, the science of deciphering molecular mechanisms is expanding rapidly. Scientists who once hunted for disease genes or sought to distinguish key concepts in evolution are now turning their attention to the details of molecular assembly and mechanism to further understand medicine and the key concepts underlying biology. The Biomolecular Interaction Network Database (BIND) was designed to store complete information about molecular assembly through a database structure in order to archive interactions and reactions arising from biopolymers (protein, RNA and DNA), as well as small molecules, lipids and carbohydrates. Detailed information about molecular mechanism, such as the chemical product(s) of an enzymatic reaction, can be encoded in BIND. The underlying ontology of the BIND database is chemistry, and as such, BIND is capable of storing information about molecular interactions to atomic resolution. The taxonomic scope of BIND is

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We document the existence of widespread firn aquifers in an elevation range of ~1200–2000 m, in the high snow‐accumulation regions of the Greenland ice sheet. We use NASA Operation IceBridge accumulation radar data from five campaigns (2010–2014) to estimate a firn‐aquifer total extent of 21,900 km2. We investigate two locations in Southeast Greenland, where repeated radar profiles allow mapping of aquifer‐extent and water table variations. In the upper part of Helheim Glacier the water table rises in spring following above‐average summer melt, showing the direct firn‐aquifer response to surface meltwater production changes. After spring 2012, a drainage of the firn‐aquifer lower margin (5 km) is inferred from both 750 MHz accumulation radar and 195 MHz multicoherent radar depth sounder data. For 2011–2014, we use a ground‐penetrating radar profile located at our Ridgeline field site and find a spatially stable aquifer with a water table fluctuating less than 2.5 m vertically. When combining radar data with surface topography, we find that the upper elevation edge of firn aquifers is located directly downstream of locally high surface slopes. Using a steady state 2‐D groundwater flow model, water is simulated to flow laterally in an unconfined aquifer, topographically driven by ice sheet surface undulations until the water encounters crevasses. Simulations suggest that local flow cells form within the Helheim aquifer, allowing water to discharge in the firn at the steep‐to‐flat transitions of surface topography. Supported by visible imagery, we infer that water drains into crevasses, but its volume and rate remain unconstrained.

Mountain glaciers comprise a small and widely distributed fraction of the world's terrestrial ice, yet their rapid losses presently drive a large percentage of the cryosphere's contribution to sea level rise. Regional mass balance assessments are challenging over large glacier populations due to remote and rugged geography, variable response of individual glaciers to climate change, and episodic calving losses from tidewater glaciers. In Alaska, we use airborne altimetry from 116 glaciers to estimate a regional mass balance of −75 ± 11 Gt yr−1 (1994–2013). Our glacier sample is spatially well distributed, yet pervasive variability in mass balances obscures geospatial and climatic relationships. However, for the first time, these data allow the partitioning of regional mass balance by glacier type. We find that tidewater glaciers are losing mass at substantially slower rates than other glaciers in Alaska and collectively contribute to only 6% of the regional mass loss.