It is known that intranuclear histones can be pernicious after entering to the extracellular space. In addition, the immunization of animals with exogenous histones leads to systemic inflammatory and toxic reactions. Abzymes—autoantibodies with enzymatic activities—are the distinctive feature of autoimmune diseases and they can be especially dangerous to humans. Here, electrophoretically homogeneous IgGs were isolated from sera of patients with multiple sclerosis (MS) by chromatography on several affinity sorbents. We present evidence that sera of all MS patients contain autoantibodies against histones and 73% of IgGs purified from the sera of 59 MS patients efficiently hydrolyze from one to five histones: H1, H2a, H2b, H3, and H4. The relative average efficiency of the histones hydrolysis was ~3.9-fold higher than that for healthy donors. The relative average activity of IgGs depends on the type of MS and decreased approximately in the following order: debut of MS, secondary progressive multiple sclerosis, remitting multiple sclerosis, remittent progressive multiple sclerosis. Similar to proteolytic abzymes of patients with several autoimmune diseases, histone-hydrolyzing IgGs from MS patients were inhibited in the presence of specific inhibitors of serine and of metal-dependent proteases, but an unexpected significant inhibition of the activity by inhibitors of thiol-like and especially acidic proteases was observed. Since IgGs can efficiently hydrolyze histones, a negative role of abzymes in the development of MS cannot be excluded.

This paper describes outstanding issues in astrophysics and cosmology that can be solved by astronomical observations in a broad spectral range from far infrared to millimeter wavelengths. The discussed problems related to the formation of stars and planets, galaxies and the interstellar medium, studies of black holes and the development of the cosmological model can be addressed by the planned space observatory Millimetron (the "Spectr-M" project) equipped with a cooled 10-m mirror. Millimetron can operate both as a single-dish telescope and as a part of a space-ground interferometer with very long baseline.

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The nonrelativistic motion with self-collision of an inelastic billiard ball in spacetime with a time machine is discussed. We consider the wormhole-type time machine, assuming that €-(radius of wormhole mouth)/(distance between mouths) << 1, and that (radius of ball)/(distance between wormhole mouths)=O ( c 2 ) . The coefficient of friction of the balls is of order E, and the balls can have an arbitrary amount of inelasticity. Solutions are sought with an accuracy up through order c4. We demonstrate that the generic class of initial data has self-consistent solutions of the equations of motion. Up to the order studied the friction does have an effect, but the inelasticity has no effect whatsoever. PACS nurnberk): 04.20.C~