Experimental batches of iodine-123-labeled beta-methyl iodophenylpentadecanoic acid ( 123 I-BMIPP) with an activity of 180 MBq/mL have been produced based on 123 I extracted from enriched 122 Te targets irradiated by accelerated deuterons at the R-7M cyclotron. It is shown that the radiochemical purity of 123 I-BMIPP in EtOH solutions exceeds 96% at an acceptable content of the main chemical impurities (Cu, Te). The conditions of 123 I-BMIPP dilution in human serum albumin (10%) solution for injection in experimental animals are determined. The biological behavior of the preparation in rats has been studied. It is established that 123 I-BMIPP is characterized by pronounced accumulation in the heart. A qualitative scintigram of the rabbit heart was obtained and showed the possibility of external detection. It is established that it is possible to judge the viability of myocardium by measuring the amount of 123 I-BMIPP accumulated in the heart.
Temporal variations in platelet levels of serotonin were found to be significantly decreased in patients with endogenous affective disorders, particularly those with the bipolar type of manic-depressive psychosis. The time course of serotonin content in these cells was not affected by either the sex or the age of the patients. In vitro incubation with lithium oxybutyrate raised mean platelet serotonin levels and stabilized their fluctuation in platelets from healthy subjects but not in those from the mental patients.It has been established beyond doubt that the serotoninergic system plays a substantial role in the pathogenesis of affective disorders. The systems of secondary messengers in neurons and platelets, the mechanisms of serotonin release, uptake, and storage by these cells, and their receptors for serotonin and imipramine have a number of similar characteristics so that platelets may be used as a convenient model for the study of serotonin transport in health and in mental disorders [9].The purpose of this study was to examine the time course of platelet serotonin in patients with affeetive disorders before and during treatment and
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.