Induction of spore differentiation is achieved within three days in Nodularia spumigena by incubating the cultures a t 35 "C in the light. Morphologically detectable sporulation and spore germination could not occur in the presence of chloramphenicol, streptomycin and penicillin. But chloramphenicol-supplemented cultures developed prominent cyanophycin granules. Synthesis of these granules seems to be a non-ribosomal phenomenon.
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