Our aim was to analyzed the significance of CD11c and CD123 positive DCs and their relations with some clinical and pathologic parameters of patients with nonsmall cell lung cancer (NSCLC). The immunohistochemical expression of CD11c and CD123, was evaluated in 40 patients with NSCLC. After analysis we found that 35.3% of the patients in the T3-4 tumour stage had a high CD11c infiltration in the tumour stroma, while 100% of the patients in the T1-2 tumour stage had low infiltration (p = 0.03). We also found that 71.4% of patients in the M1 stage had a high infiltration with CD123 in the tumour stroma, whereas only 15.6% of patients without metastases had high infiltration, analogous data are also found in comparing the distribution of CD123 in the tumour border (p = 0.002 or p = 0.002). Comparing the density of CD123 in the border of lymph node involvement, we found that only 7.14% of patients without metastases had low infiltration with dendritic cells, whereas in patients with metastatic lymph nodes that percentage was 41.7% (p = 0.008). In conclusion results suggest that CD11c-and CD123-positive DCs play an important role in antitumour immunity and can be predictive factor for tumour development in patients with NSCLC.
Simultaneous occurrence of tuberculosis and lymphoma is a rare combination. A primary malignant disease such as Hodgkin's disease (HD) can cause inhibition of cell-mediated immunity, which predisposes to concomitant tuberculosis infection. A congenital and acquired immune deficiency, the presence of autoimmune diseases suggests the development of tuberculosis. There is a close link between infectious mononucleosis caused by the Epstein-Barr virus and the development of Hodgkin's disease. We are describing a patient, aged 52 with simultaneous occurrence of tuberculosis combined with Hodgkin's lymphoma in a single cervical lymph node material developed with bilateral malignant pleural effusions and ascites, as the Hodgkin's disease has been determined at IV stage according to the Ann Arbor criteria.
Introduction:The introduction of a foreign body in the respiratory tract is a serious global problem requiring urgent medical assistance. Purpose: The aim of the study is to assess the applicability of the Virtual bronchoscopy with MDCT for patients (adults and children) with suspected foreign body. Methods: To all 9 patients Virtual bronchoscopy and Fiberoptic bronchoscopy were carried out. The studies were carried out with an optimized protocol. In order to compare the results of FB and VB the sensitivity and precision indicators were determined. Results: When comparing the results of the study of patients with suspected foreign body, both methods established 4 positive results each (44.45%). Conclusions: VB is particularly reliable and suitable for children and adults with poor general condition. The results of VB with MDCT could be used for early diagnosis of suspected foreign bodies.
OBJECTIVE:The purpose of this study is to answer the question whether the treatment of these patients leads to control of respiratory failure by relieving and eliminating dyspnea and preserving the patients' ability to care for themselves, as well as achieving reduction of the number of hospitalizations of patients with unsuccessful pleurodesis and effusion persistence. MATHERIAL AND METHODS: 165 patients with malignant pleural effusions were treated in the Clinic of Thoracic Surgery for the period 01 January 2013 -31 May 2016. 70 patients underwent surgeries with single-port VATS, 66 patients were operated on with conventional VATS, while 29 patients were treated with thoracocentesis and drainage. RESULTS: Of all 165 alone 5 patients, constituting 3.03% of the total number of patients, had to be admitted to the hospital for a second time due to reaccumulation of pleural effusion within the next 30 days. Satisfactory dyspnea control was established, allowing the patients to take care of themselves. CONCLUSION:The surgical procedures -single-port and conventional VATS surgeries, thoracocentesis, drainage and placement of long-term pleural catheter with, or without, pleurodesis constitute part of the procedures achieving control over dyspnea in patients with MPE.
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