A Combination of Hodgkin's Lymphoma and Tuberculosis occurred with Bilateral Malignant Pleural Effusions

Abstract

Simultaneous occurrence of tuberculosis and lymphoma is a rare combination. A primary malignant disease such as Hodgkin's disease (HD) can cause inhibition of cell-mediated immunity, which predisposes to concomitant tuberculosis infection. A congenital and acquired immune deficiency, the presence of autoimmune diseases suggests the development of tuberculosis. There is a close link between infectious mononucleosis caused by the Epstein-Barr virus and the development of Hodgkin's disease. We are describing a patient, aged 52 with simultaneous occurrence of tuberculosis combined with Hodgkin's lymphoma in a single cervical lymph node material developed with bilateral malignant pleural effusions and ascites, as the Hodgkin's disease has been determined at IV stage according to the Ann Arbor criteria.

Active Tuberculosis Risk Associated with Malignancies: A 4-Year Retrospective Study in a Tertiary Care Hospital

“…35 Mycobacterial infections may lead to chronic persistent inflammatory process. 39 There is enough evidence that MTB can induce damage to cellular DNA involved in inflammatory carcinogenesis. 39 The pathogenesis hypothesized is that mycobacterial tuberculous infection causes direct DNA damage and apoptosis inhibition, which increase mutagenesis of progeny cells, combined with angiogenesis favoring tumorigenesis.…”

“…39 There is enough evidence that MTB can induce damage to cellular DNA involved in inflammatory carcinogenesis. 39 The pathogenesis hypothesized is that mycobacterial tuberculous infection causes direct DNA damage and apoptosis inhibition, which increase mutagenesis of progeny cells, combined with angiogenesis favoring tumorigenesis. 35 Specifically, various mycobacterial cell wall components are hypothesized to induce the production of nitric oxide and reactive oxygen species which are involved in mutagenesis.…”