Multiple primary malignant tumors first were described by Billrath in 1889 (1). Until the extensive and detailed study of Warren and Gates (2) in 1932, multiple primary tumors were considered medical curiosities.The clinical problems and special medical aspects of these patiente account for the numerous case reporte and clinical series in the literature (3-10). It is obvious that regardless of the siae and thoroughness of a olinical series, there is always a possibility of error if no postmortem examination is made. MATERIALS AND METHODSThe records of 16,444 postmortem examinations inclusive) on file in the Department of Pathology at Cleveland Metropolitan General Hospital were reviewed. At least 1 malignant tumor wm recorded in 3,321 autopsy protocols. More than 1 primary malignant neoplasm was found in 177 mes. All available gross and microscopic findings were analyzed. Hospital records and the microscopic slides were reviewed.

Bibliographic Ipd cesThis publication is listed ín bibliographic services, including Current Contents® and Index Medicus. Drug DosageThe authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication.However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved.No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

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