Multiple Primary Malignant Tumors*

Hajdu, Steven I.; Hajdu, E.O.

doi:10.1111/j.1532-5415.1968.tb03965.x

Cited by 72 publications

(38 citation statements)

References 13 publications

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“…T w o of these patients (2 and 6 years' survival) underwent partial resection of their proximal trachea. T h e third patient (7 years' survival) received 3,000 rads external radiation and subsequently radon seeds in his lower tracheal tumor after bronchoscopic biopsy. T h e presence of disease was repeatedly proved by positive paratracheal and supraclavicular node biopsies in all 3 cases.…”

Section: Nomentioning

confidence: 99%

Carcinoma of the trachea.Clinicopathologic study of 41 cases

Hajdu

Huvos

Goodner

et al. 1970

Cancer

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130

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During a period of 33 years, 41 patients with primary carcinoma of the trachea were treated at Memorial and James Ewing Hospitals. Thirty of these patients had epidermoid carcinoma, 7 had adenoid cystic carcinoma, and 4 had mucus‐secreting adenocarcinoma. In view of the cryptic symptomatology, tracheal carcinoma must be considered in the differential diagnosis in patients with chronic cough, hemoptysis, and negative chest roentgenogram. The prognosis of tracheal carcinoma appears to depend mainly upon size and histologic type of the primary tumor. The prognosis of epidermoid and mucus‐secreting adenocarcinoma appears to be grave. Less than 25 percent of the patients with epidermoid carcinoma survived one year or longer. Adenoid cystic carcinoma carried a much better prognosis, however. These tumors have a slow and insidious course, usually recur, and metastasize several years after initial treatment. Small tracheal tumors can be treated either by endoscopic excision or partial resection of the trachea. In the case of extensive localized disease, the combination of surgery and irradiation is the treatment of choice.

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Section: Nomentioning

confidence: 99%

Carcinoma of the trachea.Clinicopathologic study of 41 cases

Hajdu

Huvos

Goodner

et al. 1970

Cancer

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130

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“…Bu nedenle onkoloji pratiğinde ikinci kanserlerin önemi giderek artmaktadır. MPMN sıklığı yayınlara göre %0,7 ile %11,7 arasında değişmektedir [3][4][5][6][7]. Bizim 5 yıllık hasta verilerimize göre de bu oran %1,2'dir ve literatür verileri ile uyumludur.…”

Section: Discussionunclassified

Multipl primer malign neoplaziler: Cumhuriyet Üniversitesi verileri

Babacan¹,

Kılıçkap²,

Sahin³

et al. 2012

CMJ

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Hastalardaki en sık ilk primer tümör jinekolojik tümörler (10 hasta, %26,3) iken, en sık ikinci primer tümör meme kanseri (7 hasta, %18,4) idi. En sık tümör birliktelikleri ise sırasıyla: jinekolojik tümörler-meme kanseri (5 hasta, %13,1), jinekolojik-jinekolojik tümörler (3 hasta, %7,9), sarkom-meme kanseri (3 hasta, %7,9), baş boyun tümörleri-akciğer kanseri (3 hasta, %7,9), üriner sistem-üriner sistem tümörleri (3 hasta, %7,9) şeklindeydi. Sonuçlar. Sonuçlarımız literatürr ile uyumludur. Kanser tanısı almış hastalar, olası ikinci kanserler, koruyucu önlemler ve tarama hakkında bilgilendirilmeli ve şüpheli lezyonlarda biyopsiden kaçınılmamalıdır.Anahtar sözcükler: Kanser, ikinci primer neoplasm, multipl neoplaziler, metakron, senkron Abstract Aim. Developments in cancer treatment and longer anticipated life period have brought out late side effects related to therapy and development of a second cancer. Multiple primary malignant neoplasms (MPMN) are described as pathological diagnosis of two or more independent primary reportable neoplasms in an individual. In this study we aimed to investigate demographic, pathological and clinical features of patients with multiple primary cancers in our center. Method. From January 2007 to January 2012, medical files of totally 3108 cancer patients were retrospectively screened. Results. Thirty-eight (1.2%) of 3108 cancer patients followed-up at our centre were diagnosed as MPMN. Of these patients, 21 (55.3%) was female, and 17 (45%) was male. While 37 patients were found to have two different primary malignant neoplasms, only one patient had three different primary cancers. The median age at the initial time of second primary cancer was 60 years (32-76). Patients with MPMN were diagnosed as synchronous neoplasm in six patients (16%) and as metachronous neoplasm in thirty-two (84%) patients. The median interval between the first and second cancers was 40 months (0-372). The most common primary tumor was gynecological cancers (n=10; 26%) and the most common secondary cancer was breast cancer (n=7; 18%). The most common cancer couplings were gynecological-breast cancer (n=5; 13%), gynecological-gynecological cancer (n=3; 8%), sarcoma-breast cancer (n=3; 8%), head and neck-lung cancer (n=3; 8%), and urinary-urinary system cancer (n=3; %8), respectively. Conclusion. Our results comply with the literature. Patients with cancer should be informed by physicians about development of secondary neoplasm, cancer prevention and screening. Clinicians should not hesitate from biopsy in suspected lesions.

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“…In a study of 177 cases of multiple primary malignancies the authors found that more than 50% of the cases showed significant cirrhosis of the liver (9). Both of our cases were known alcoholics with liver disease and both demon strated impaired cell-mediated immunity when skin-tested although the second patient was only tested with PPD.…”

Section: Commentmentioning

confidence: 99%

“…In the meantime, we suggest that patients with chronic liver disease should be carefully followed for possible development of a malignant neoplasm other than hepatoma. It is striking that among 177 cases of multiple primary malignancies only nine were diagnosed before the postmortem examina tion and no cancer was diagnosed (or suspected) in roughly one fourth of them (9).…”

Section: Commentmentioning

confidence: 99%

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Multiple Primary Malignancies in Patients with Alcoholic Liver Disease

Mihas¹,

Doos²

1975

Oncology

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Two patients, each with three primary malignant neoplasms are presented. In an effort to identify a possible common denominator of induction of these tumors, it was found that both patients were alcoholics with liver disease, and that both had impaired delayed hypersensitivity reactions. The possibility of an increased susceptibility to cancer among alcoholics with liver disease is noted and the need for careful follow-up of these patients is suggested.

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Multiple Primary Malignant Tumors*

Cited by 72 publications

References 13 publications

Carcinoma of the trachea.Clinicopathologic study of 41 cases

Carcinoma of the trachea.Clinicopathologic study of 41 cases

Multipl primer malign neoplaziler: Cumhuriyet Üniversitesi verileri

Multiple Primary Malignancies in Patients with Alcoholic Liver Disease

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