SummaryThirty healthy patients were randomised to receive either a single bolus dose of rocuronium 0.6 mg.kg-' or vecuronium 0.1 mg.kg-' during halothane anaesthesia. Onset time, duration 25, duration 75 and train-offour 70 were measured. The onset of neuromuscular blockade following rocuronium was more rapid than vecuronium ( p = 0.0001). AN other pharmacodynamic parameters were similar. During the first minute following injection of the neuromuscular blocking agent, the heart rate increased by 36% in the rocuronium group but remained stable in those patients who received vecuronium (p = 0.oooS). No adverse effects were noted in either group.
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