Pain on Injection of Rocuronium Bromide

Steegers, Monique; Robertson, E. N.

doi:10.1213/00000539-199607000-00065

Cited by 94 publications

(40 citation statements)

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“…The pain on injection of rocuronium is signifi cant, both in incidence [1][2][3] and intensity. It has been described as a "burning" sensation [1][2][3][4].…”

Section: Discussionmentioning

confidence: 99%

“…It has been described as a "burning" sensation [1][2][3][4]. Pain has been found to occur immediately on injection, in both awake and anesthetized patients [1][2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…The incidence is high (50%-80%) [3], and the pain is at times severe and burning [1][2][3][4]. Various strategies have been studied to reduce the discomfort drug at the start of the anesthetic that may or may not cause pain.…”

Section: Abstract Rocuronium · Pain · Narcotics · Neurosurgical Patimentioning

confidence: 99%

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Effect of narcotic pretreatment on pain after rocuronium injection: a randomized, double-blind controlled comparison with lidocaine

et al. 2007

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Various strategies have been studied to reduce the discomfort of rocuronium pain. These studies have shown fentanyl and lidocaine to be effective in reducing the incidence of pain on rocuronium injection. This prospective, randomized, and double-blind study was carried out on 80 neurosurgical patients for whom pain on rocuronium injection was assessed after pretreatment with lidocaine, fentanyl, sufentanil, or normal saline. The 80 neurosurgical patients were randomly allocated to anyone of the groups to receive lidocaine, fentanyl, sufentanil, or normal saline prior to being given rocuronium. The patients were asked about any discomfort in the hand, and also to rank that discomfort on a 5-point scale. In the normal saline group, the incidence of pain was 95%, of which 90% had very severe pain. In the lidocaine group, only 10% of patients reported pain, which was mild in nature. In the fentanyl group, 95% of patients had pain, of whom 25% had severe to very severe pain. In the sufentanil group, 85% of patients reported pain, of whom 25% fell into the severe to very severe group. We found that lidocaine was best at decreasing the incidence of pain on intravenous (i.v.) injection of rocuronium. Although the incidence of pain on injection of rocuronium with both fentanyl and sufentanil was high, the intensity was definitely reduced, with most patients falling in the mild pain group.

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“…The pain on injection of rocuronium is signifi cant, both in incidence [1][2][3] and intensity. It has been described as a "burning" sensation [1][2][3][4].…”

Section: Discussionmentioning

confidence: 99%

“…It has been described as a "burning" sensation [1][2][3][4]. Pain has been found to occur immediately on injection, in both awake and anesthetized patients [1][2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of narcotic pretreatment on pain after rocuronium injection: a randomized, double-blind controlled comparison with lidocaine

et al. 2007

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“…Pain is one of the major disadvantages of rocuronium, which is used during induction of anesthesia [3,5,6]. Even at subparalyzing doses, 50-100% of patients complain of intense pain [3,6,7].…”

Section: Casementioning

confidence: 99%

“…Even at subparalyzing doses, 50-100% of patients complain of intense pain [3,6,7]. The exact mechanisms through which rocuronium causes pain have not been elucidated.…”

Section: Casementioning

confidence: 99%

Superficial venous thrombophlebitis caused by rocuronium

et al. 2010

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Pain is one of the major disadvantages of rocuronium, which is used during induction of anesthesia. Even at subparalyzing doses, 50-100% of patients complain of intense pain. Sudden flexion and withdrawal movement in the wrist or arm have been reported following rocuronium use in many papers. No information about risk factors leading to this withdrawal movement or pain on injection is available and whether this reaction leads to erythema or to venous sequelae (i.e. thrombosis and thrombophlebitis) has not been systematically investigated. However, in both of our cases, visible reactions occurred and both patients were diagnosed with venous superficial thrombophlebitis. Therefore, we believe that rocuronium-related pain may, in part, be because of direct venous injury.

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