In order to achieve Process Intensification through monolithic micro-reactors in bio-and chemical technology we examined the processing strategy in the human body, taking the liver as a typical organ. The macro-and micro-architectural structure can be mimicked by using nano-structured micro-porous polymers which were used as support in tissue engineering and bioprocess intensification. It was shown that these materials could be used as bone transplant and they are integrated into the body. Their integration could be predicted through in vitro experiments. Metallic versions of these structures with a hierarchy of pore size were produced in order to obtain catalytic bio-or chemical reactors operating at high temperature and/or pressure.