Objective To examine the possible role of ischaemic at 0, 2 and 9 days after treatment, and expressed as a percentage of the total renal uptake. preconditioning (IPC), an adaptive pathophysiological phenomenon that increases tolerance to ischaemiaResults The mean (sem) maximum decrease in left renal function, to 14.5 (4.3)% of the total, occurred on day reperfusion (I-R) injury, in renal protection when rats are presented with an I-R challenge.2 in Group C. The equivalent value in Group D showed relative preservation of function, at 36.0 (3.5)% (P= Materials and methods Female Wistar rats (n=36) were divided randomly into four groups: (A) sham-operated 0.001 compared with Group C). The mean left renal function improved by day 9, to 39.6 (6.7)% (Group controls; (B) IPC only; (C) renal ischaemia (RI) only; and (D) IPC+RI. The left kidney in groups B and D C) and 48.6 (1.5)% (Group D). The mean left renal function in Group B (50.5-53.9%) did not diCer from was preconditioned with four cycles of renal artery occlusion lasting 4 min, each occlusion separated by that in controls (49.4-51.4%). Conclusion An IPC regimen applied 5 min before RI in 11 min of reperfusion. The ischaemic insult, applied in groups C and D, comprised 40 min of sustained left the rat significantly protects it from the functional impairment associated with ischaemia and reperrenal artery occlusion. In Group D, the IPC cycle was completed 5 min before the start of the ischaemic fusion.
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