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In addition to the previously reported alkaloids from Mitragyna speciosa a number of additional oxindole alkaloids were isolated, three of which are new. These have been named mitrafoline, isomitrafkline and isospeciofoline. Mitragynine oxindoles A and B were found for the first time in plant material while corynoxeine and the corynoxines were found for the first time in the genus Mitragyna. Examination of thirteen monthly samples of leaves showed that mitragynine and paynantheine remained the dominant indole alkaloids of the mature plant throughout the entire period of collection. TRAGER, LEE, PHILLIPSON, HADDOCK DWUMA-BADU and BECKETT [4]. Since then number of other sample: of Mitragyna speciosa consisting o: leaves and young twigs from Thailanc have been examined. More sensitivc

Mitragyna speciosa K O r t h. is a tree which grows to a height of about 3 to 4 m. in swampy ground in Malaya, Thailand and other countries in Southeast-Asia. The use of its leaves, bark etc., has been reported by R i d 1 e y (1897) and H o o p e r (1907) as an antiopiate, though H o l m e s (1907) stated that it was used as an opium substitute. In Thailand the leaves, known as ,kratomL a t one time were considered to be a n opium substitute and also a cure for the opium habit. However, this view is no longer accepted (4 th Report of the Government Laboratory, Bangkok, 1925). In Malaya the tree is sometimes known as Mitragyna religiosa.