No abstract

Exhaled breath condensate has been collected in other species and used as a non-invasive method of evaluating airway disease by measurement of various markers in the fluid, including hydrogen peroxide, nitric oxide, leukotrienes and prostaglandins. We describe a novel technique for the collection of exhaled breath condensate from cats, which enabled collection of fluid and measurement of its hydrogen peroxide concentration. Further studies will be needed to establish the value of this technique in the investigation of feline respiratory disease.

BackgroundHeart disease is an important cause of morbidity and mortality in cats, but there is limited evidence of the benefit of any medication.HypothesisThe angiotensin‐converting enzyme inhibitor benazepril would delay the time to treatment failure in cats with heart disease of various etiologies.AnimalsOne hundred fifty‐one client‐owned cats.MethodsCats with heart disease, confirmed by echocardiography, with or without clinical signs of congestive heart failure, were recruited between 2002 and 2005 and randomized to benazepril or placebo in a prospective, multicenter, parallel‐group, blinded clinical trial. Benazepril (0.5‐1.0 mg/kg) or placebo was administered PO once daily for up to 2 years. The primary endpoint was treatment failure. Analyses were conducted separately for all‐cause treatment failure (main analysis) and heart disease‐related treatment failure (supportive analysis).ResultsNo benefit of benazepril versus placebo was detected for time to all‐cause treatment failure (P = .42) or time to treatment failure related to heart disease (P = .21). Hazard ratios (95% confidence interval [CI]) from multivariate analysis for benazepril compared with placebo were 1.00 (0.57‐1.74) for all‐cause failure, and 0.99 (0.50‐1.94) for forward selection and 0.93 (0.48‐1.81) for bidirectional selection models for heart disease‐related failure. There were no significant differences between groups over time after administration of the test articles in left atrium diameter, left ventricle wall thickness, quality of life scores, adverse events, or plasma biochemistry or hematology variables.Conclusions and Clinical RelevanceBenazepril was tolerated well in cats with heart disease, but no evidence of benefit was detected.

A four-year-old, male Cocker Spaniel was presented for investigation of pelvic limb stiffness. There was palpable effusion of both tarsi, and analysis of synovial fluid from these joints indicated previous haemorrhage. After further investigation a diagnosis of idiopathic immune-mediated thrombocytopenia was made. The dog responded to treatment with prednisolone and azathioprine. To the authors' knowledge, this is the first reported case of confirmed haemarthrosis as the sole presenting clinical sign for canine idiopathic immune-mediated thrombocytopenia.