S. fastigiatum var. fastigiatum was dried, ground and administered to 2 cattle by ruminal cannula at 5 g/kg daily for 5 days a week during 107 and 140 days, respectively. At the end of the study, the animals were sacrificed and cerebellum samples were obtained for histological study. It was shown that there was Purkinje cell vacuolization in the treated animals. The Purkinje cells showed high binding affinity for lectins from Concanavalia ensiformis (Con-A) and succinyl-WGA (sWGA). Staining was also evident for Triticum vulgaris (WGA) and Ricinus communis-I (RCA-I); irregular for Arachis hypogaea (PNA) and Glycine max (SBA) and poor to no reactivity to Dolichos biflorus (DBA), Ulex europaeus-I (UEA-I) and Bandeirea simplicifolia (BS-I) lectins. These results suggest that S. fastigiatum var. fastigiatum causes a glycolipid storage disease.
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