Our results indicate that cytological surveiliance is acceptably safe provided that biopsy is advised if dyskaryosis persists. IntroductionFormerly a cervical smear that showed mild

Summary. The effect of vincristine on the platelet count of rats is described. It was found that, depending upon dosage, the drug can cause either a thrombocytosis or marrow hypoplasia with thrombocytopenia in normal rats. Thrombocytosis was found even after prolonged treatment with vincristine when this was given at appropriate dosage. The thrombocytosis promoting effect of the drug was not enhanced by an increase in the splenic platelet pool or decreased by splenectomy. However, it was abolished when prior treatment was given to suppress marrow thrombopoiesis.

Thrombocytosis was produced in rats by repeated doses of vincristine over a period of three weeks. Using ⁷⁵Se Selenomethionine to assess platelet production, evidence was obtained that vincristine induces an increase in the platelet count by causing an increase in thrombopoiesis.

The results of an assessment of the macrophage electrophoretic mobility test in cancer diagnosis are described. We found that the test did not reliably distinguish between a group of 18 patients with benign disorders and a group of 25 with malignant disease.

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