Vincristine Therapy of Thrombocytopenias

Many patients with thrombotic thrombocytopenic purpura (TTP) fail to respond to daily plasmapheresis and the results of alternative treatments have been inconsistent. Vincristine was given weekly with continued plasmapheresis to eight patients who were refractory to plasmapheresis, antiplatelet agents, and/or corticosteroids. A rapid response to the vincristine occurred in all eight patients in 5 days with a marked rise in the platelet count and resolution of symptoms. The results in these patients suggest that early initiation of vincristine therapy in conjunction with plasmapheresis is useful in TTP.

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Rapid improvement of thrombotic thrombocytopenic purpura with vincristine and plasmapheresis

Welborn

Emrick

Acevedo

1990

American J Hematol

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Gold‐Induced Thrombocytopenia: Response to Vincristine?

Ball

1977

Arthritis & Rheumatism

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Successful treatment of recurrent thrombotic thrombocytopenic purpura with plasmapheresis and vincristine

et al. 1994

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An adolescent girl with severe thrombotic thrombocytopenic purpura (TTP) remained in a critical condition after 3 weeks of combined treatment with antiplatelet drugs, plasma infusions and plasma exchange. The introduction of vincristine resulted in gradual improvement and eventual complete remission which lasted for 2 years. When she relapsed, immediate improvement was observed with the combined treatment of plasmapheresis and vincristine. She has now been in complete remission again for 10 months. It is suggested that plasmapheresis plus vincristine should be used as the initial treatment for children with TTP.

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Vincristine Therapy of Thrombocytopenias

Cited by 8 publications

References 6 publications

Rapid improvement of thrombotic thrombocytopenic purpura with vincristine and plasmapheresis

Rapid improvement of thrombotic thrombocytopenic purpura with vincristine and plasmapheresis

Gold‐Induced Thrombocytopenia: Response to Vincristine?

Successful treatment of recurrent thrombotic thrombocytopenic purpura with plasmapheresis and vincristine

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