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The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

No abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

This is a monograph recording an investigation in quantitative physiology. Regulations in organisms are maintenances of relative constancies. They are described from suitable data by selected relations of the following sorts :(1) Variations, especially in the successive values found for one sort of measurement in an individual. These represent the results of all those events that antagonize the occurrence of wider variations.(2) Changes and exchanges as correlated with excesses over, or deficits under, the control values (contents). These are rates of processes, and express what is done to recover the usual physiological state.(3) Behaviors that exhibit preferences for environments which either promote or prevent exchanges of diverse components. Water is chosen as the prototype of component that tends to be in quantitatively regular amounts in living units. Data for the dog show in how far water contents (body weights), intakes, and outputs vary from hour to hour and from day to day ; and how the rates of intakes and outputs are modified with each experimentally provided content. The latter relation is investigated both in stationary states of unusual content, and in recoveries from them. Preservation of content may be regarded as a pattern of particular relations among the rates provided in diverse paths of exchange. Man, frog, and many other species of animals, including several of invertebrates, manifest similar relations in water exchange. Organs, tissues, and cells are also recognized as having the pattern. From these materials the general features common to many living units are formulated. Quantitative differences among species are also ascertained. A variety of other measurements, particularly upon blood and other parts, is correlated with water content, to characterize the physiological states of water excess and deficit. Thus an intensive and comprehensive account of water relations of animals and their tissues results. Analogous data are set forth concerning other quantities than water. Some of these are heat, glucose, oxygen, carbon dioxide, lactate, frequency of heart beat, and blood pressure. For each a similar pattern of equilibration is found. ABSTEACTThe -uniformities and the contrasts among them are pointed out.The general forms of variation in content, of time relations in recovery, and of rates of exchange in relation to excesses and deficits (equilibration) are induced.Simultaneous equilibrations of two or more such quantities are studied.The interplay of quantities indicates the organism's choices in handling at one time the various items that call for recovery. It is inferred that the organism is a compound of relations among components in mutual adjustment. Descriptive procedures are illustrated that exhibit the multiple relations in comprehensible manners.These selected relations among data are manifestations of the processes commonly meant by the term physiological regulations. They provide a quantitative means of visualizing what organisms do to maintain constancy not only of compositio...

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