THAT the parenteral introduction of foreign protein in the form of antisera is not infrequently accompanied by more or less important constitutional and local manifestations of irritation or intoxication is generally appreciated. Fortunately, such symptoms consist, as a rule, simply in the development, a few (2 to 14) days after the injection, of urticarial and erythematous eruptions, and joint or muscle pains, accompanied sometimes by a certain degree of pyrexia. The patient is
The price the Raclium Commiuittee have at present. fixed. for emanation is 4d. per millicurie for freehospital patients and 1Is 6da per millicurie for private patients.If the resilt of the method which I liave been employinIg appeals to othiers thle cost of treatment will be less and more-patients can be dealt with.Emanation is so valuable that I endeavqur. to keep it in constant use until it is practically exhausted. For instance, in a case of eancer of the cervix uteri withi iuvolvement of' the vagina, I have used an in-itial dose of 24 millicuLries in six needles for four dlays. Hleave them. in the first position -usually the posterior lip, as it is the lhardest to get atfor twenty:four hour., in thle anterior lip for thiirty bhOurs, and, lastly, in the vaginal wall for f9rty hours. The emanation will be reduced by tthat time to twelve millicuries, so that tlle patient would receive an average dose rouglhly equivalent to 18 milligrams of radium for ninety lhours, or 1,620 milligram hours. I havo then used the samie needles for malignant glands, or, a large rodent ulcer for two days, and for a small rodent ulcer for two more; These-immediate symptomlis may give place to those of CO poisoning, if thle latter gas lhas been inhaled, and imay tllus becoie -virtuLally miaslked in tllc more evidenit state of CO poisoning.The irritanit gases presenit in smoke, lhowever, wlhen inhlaled unider such circtumstalnces, produce after a celtain lapse of timie, generally a few hours, a xvell-marked relmlote effect upon tlle lunUs. In tlle luore fortuijato cases bronchitis is superadded to tlle sym1ptoims of CO poisoning, but in severe cases-acute oedema of the lungs, or even-bronchoplieuumonia, may develop.Tlle development of these complications may iaturally increase tlle dangers of CO poisoninlg very consifTerably, and cases are on iecord in \vhiclh the greatest difficulty has -been encountered fromi this cause.Tllat these comiplications are due to tlle action of the irritant gases present in suiolkc is abunidantly proved-first, by the fact tliat in cascs of CO poisonina uncomplicated by smuoke pulnioinary symiiptoms, suclh -as -liave been described above, nlever develop; secondly, that in tlhose cases iit wlich tlhe julmionary .syimptoms -described lhave developed thire. is an invariable history,.when suclh is obtainable, of exposure to sm-ioke; and, tlirdtly, that
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