During a 10 year period, a renal tract anomaly was suspected on antenatal ultrasound in 125 fetuses, an incidence of five per 1000 births. 107 live births resulted. Three of six babies with renal failure were stented antenatally. A chromosome anomaly was present in three fetuses (2.4%). No live birth resulted in 14 pregnancies associated with oligohydramnios and no visible fetal bladder. Of those with renal agenesis or bilateral cystic dysplasia, one had a chromosome defect and a further four had extrarenal anomalies. Nine fetuses demonstrated isolated parenchymal hyperechogenicity and trisomy occurred in two of four with bilateral change in enlarged kidneys. All 14 babies with unilateral renal cysts had normal renal function postnatally, but only three of the cystic kidneys showed function. Antenatally, typical multicystic change was seen in 10, and smaller unevenly distributed cysts in four kidneys. Contralateral parenchymal echogenicity and/or pelvicalyceal distension indicating dysplasia was identified in four fetuses. Of 78 fetuses with isolated pelvic with or without calyceal distension the outcome was completely normal in 59% with unilateral, and in 48% with bilateral changes. One baby with unilateral and three with bilateral changes required dialysis or renal transplantation. One of four babies with antenatal ureteric distension had renal failure. Only one of six fetuses with bladder distension is alive in renal failure after in utero stenting.
During the 10 years 1984-1993, a total of 438 fetuses and children with a congenital abnormality, identified antenatally or in the first year of life, were registered from the North Tees Health District with the Northern Region Congenital Abnormality Survey (NorCAS). This represented an abnormality rate of 2% of all births. In total, 252 structural abnormalities (57.5%) were detected by antenatal ultrasound examination. In spite of a targeted education programme, identification of cardiac lesions remained poor. The detection of structural abnormality by antenatal scan rose from 52% in 1984 to 85% in 1993, due mainly to improvements in image quality and resolution of ultrasound equipment. Also important was audit, based both on review of images and feedback from a comprehensive central register (NorCAS).
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