Congenital anterior abdominal wall defects in the North of England, 1986-1996: occurrence and outcome

Rankin, Judith; Dillon, E.; Wright, Chris

doi:10.1002/(sici)1097-0223(199907)19:7<662::aid-pd607>3.0.co;2-c

Cited by 151 publications

(216 citation statements)

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“…Omphalocele is frequently seen in the context of congenital syndromes with multiple associated anomalies, Jwa E, et al: The Prognosis of Gastroschisis and Omphalocele such as Beckwith-Wiedemann syndrome, cloacal exstrophy, OEIS (omphalocele, exstrophy, imperforate anus, spinal defects) complex, Cantrell's pentalogy [3,4]. Cardiac anomaly is the most frequent anomaly in omphalocele (39%-45%) as in our study [11,12].…”

Section: Discussionsupporting

confidence: 67%

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The Prognosis of Gastroschisis and Omphalocele

Jwa

Kim

et al. 2014

J Korean Assoc Pediatr Surg

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Purpose: Gastroschisis and omphalocele are major anterior abdominal wall defects. The purpose of this study was to analyze the clinical differences and mortalities of gastroschisis and omphalocele in Asan Medical Center. Methods: A retrospective review of the medical records was conducted of 103 cases of gastroschisis and omphalocele from September 1989 to February 2013 in Asan Medical Center in Korea. Results: There were 43 cases (41.7%) of gastroschisis and 60 cases (58.3%) of omphalocele. There was a female predominance in both gastroschisis (60.5%) and omphalocele (58.3%). The average gestational age at delivery was 36.7±0.4 weeks for both groups. The mean birth weights were 2,381.9±80.6 g for gastroschisis and 2,779.4±82.8 g for omphalocele (p=0.001). Mean maternal ages in the gastroschisis and omphalocele groups were 27.5±0.7 years and 30.5±0.7 years, respectively (p=0.002). Associated malformations were documented in 13 infants (30.2%) with gastroschisis and 46 infants (76.7%) with omphalocele (p<0.001). All of gastroschisis patients except one underwent surgery including 31 primary repairs and 11 staged repairs. Fifty-two infants with omphalocele underwent surgery−primary repair in 41 infants and staged repair in 11 infants. Among 103 cases, 19 cases (18.4%) expired. Mortality rates of gastroschisis and omphalocele were 23.3% (10/43 cases) and 15.0% (9/60 cases), respectively (p=0.287). The main causes of death were abdominal compartment syndrome (6/10 cases) in gastroschisis, respiratory failure (4/9 cases) and discharge against medical advice (4/9 cases) in omphalocele. Conclusion: Gastroschisisis was associated with younger maternal age and lower birth weight than omphalocele. Associated malformations were more common in omphalocele. The mortality rates did not make a statistical significance. This might be the improvement of treatment of cardiac anomalies, because no patient died from cardiac dysfunction in our study. Furthermore, abdominal compartment syndrome might be the main cause of death in gastroschisis.

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Section: Discussionsupporting

confidence: 67%

“…The prevalence of omphalocele has been reported to be 1.22-2.76 per 10,000 births, and gastroschisis, 0.94-3.01 per 10,000 births [3][4][5]. The exact etiology of these anomalies is unknown.…”

Section: Discussionmentioning

confidence: 99%

The Prognosis of Gastroschisis and Omphalocele

Jwa

Kim

et al. 2014

J Korean Assoc Pediatr Surg

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“…Other studies around the world have found increases in gastroschisis prevalence, along with a decrease in omphalocele. 4,6 -9 Rankin et al 7 reported an increase in the incidence of gastroschisis without a corresponding change in omphalocele. Theories to account for these incidence changes have included an environmental agent, inaccurate classification, limited family histories, and a higher familial recurrence risk.…”

Section: Discussionmentioning

confidence: 99%

Omphalocele and gastroschisis: An 18-year review study

Hwang

Kousseff

2004

Genetics in Medicine

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were retrieved through the database and analyzed through chart review.Results: There were 127 cases of omphalocele and 121 cases of gastroschisis. Ninety-three of the 127 probands with omphalocele had karyotype determinations and 20% were abnormal; for gastroschisis, 37 had cytogenetic studies and none had chromosomal anomalies. Seventy-six percent of the probands with omphalocele had associated abnormalities; twenty-three percent of the probands with gastroschisis, none of which were syndromic, had associated anomalies. The prematurity rate for omphalocele was 42% and mortality was 22%; for gastroschisis, the figures were 57% and 9%, respectively. There were no significant differences in teratogen exposure between the two groups. Familial cases of both defects occurred in Ͻ 4%, and the prevalence of dizygous twinning was increased in both groups. Mean maternal age was 21.8 years for the gastroschisis group, 27.2 years for the omphalocele group. Conclusions: In this study, the number of cases of omphalocele and gastroschisis were similar, compared to the expected 3:2 ratio, suggesting an increase in the occurrence of gastroschisis. Cases with omphalocele had more syndromic and nonsyndromic anomalies, more chromosomal anomalies, a higher mortality rate, and older mothers. Genet Med 2004:6(4):232-236.

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“…Other birth defects, such as gastroschisis, also have increased rates in teenage mothers. [18][19][20][21] Unfortunately, it was not possible to analyse the data by any socio-economic measure, however, the association between teenage mothers, poor sociodemographic environment and adverse reproductive outcome is well known. 22,23 Contrary to earlier Australian studies, 24 we found in the logistic regression model a decreasing risk of NTDs with increasing maternal age, independent of the number of previous pregnancies.…”

Section: Discussionmentioning

confidence: 99%