The patient was 65 years old when she developped spontaneous bleeding. She did not have a family history of abnormal bleeding and profered clear evidence of normal hemostasis before.Bleeding time, platelet aggregation induced by collagen were abnormal. VIII related antigen, ristocetin cofactor were 10 per cent the normal range while VIII procoagulant activity was 50%.Interaction with rabbit sub endothelium was studied: contact and adhesion were 50% of the normal range and thrombi were absent.Infusion of cryoprecipitate corrected partially von Willebrand abnormalities while platelet aggregation induced by collagen remained unchanged. Velocity of platelet aggregation induced by collagen, VIII related antigen and ristocetin cofactor increased moderately after corticotherapy.The association of an acquired thrombopathy and von Willebrand’s disease in a patient with chronic lymphocytic leukemia lead one to wonder about possible relationship between these diseases in this case.
SummaryA preliminary characterization of a fibrinolytic inhibitor released by human umbilical vein endothelial cells in primary culture is reported. This molecule of Mr comprised between 2 × 105 and 106 and of μ2 mobility precipitates at 43% ammonium sulphate saturation and is totally adsorbed on Concanavalin A Sepharose 4 B. A possible relationship with a macroglobulins is discussed.
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