1978
DOI: 10.1016/0049-3848(78)90309-2
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Production of a fibrinolytic inhibitor by cultured endothelial cells derived from human umbilical vein

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Cited by 114 publications
(34 citation statements)
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“…Furthermore, these inhibitors appear to differ between different cell types. The secretion of Uk inhibitors by murine macrophages, which also synthesize a Uk-type PA (15,16, manuscript in preparation), as well as by hepatoma tissue culture cells (36), endothelial cells (37)(38)(39), and other cell types (40)(41)(42), further underlines the possible generality of these phenomena.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, these inhibitors appear to differ between different cell types. The secretion of Uk inhibitors by murine macrophages, which also synthesize a Uk-type PA (15,16, manuscript in preparation), as well as by hepatoma tissue culture cells (36), endothelial cells (37)(38)(39), and other cell types (40)(41)(42), further underlines the possible generality of these phenomena.…”
Section: Discussionmentioning
confidence: 99%
“…Endothelial cells secrete several proteins involved in different aspects of the hemostatic response including vWf, which promotes platelet adhesion and aggregation (8,12), protein S, which potentiates the anticoagulant action of protein C (40,41), and both plasminogen activators (42,43) and plasminogen activator inhibitor (44), which together regulate activation of fibrinolysis. Therefore, control of endothelial cell synthesis and secretion of these proteins is of central importance in coordinating the local hemostatic response to vessel injury.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, cultured rabbit (6,7) and human (8)(9)(10)(11) endothelial cells were found to be associated with an antifibrinolytic activity, suggesting that endothelium itself also may produce molecules that modulate the fibrinolytic activity of the vessel wall. However, no such inhibitor activity has been detected in confluent bovine aortic endothelial cells (BAEs) (9,12).…”
mentioning
confidence: 99%