The closed chamber technique solves the drawbacks related to open chamber evaporimeters. Especially, it extends the measurement range to high evaporation rates and TEWL measurements can be performed practically at any anatomical sites and measurement angle. By the use of a closed chamber the disturbance related to external or body-induced air flows on the measurement can be avoided.
The capacitive measuring principle of the MoistureMeter was demonstrated in an experimental arrangement. Although both instruments yielded equivalent data with the base formulation, the MoistureMeter was a more sensitive device than the Corneometer CM 820 and independent of added salt in the formulations.
A three-layer model of stratum corneum, epidermis/dermis and subcutaneous fat has been developed for the capacitance of an open-ended coaxial line in contact with human skin. Applying the model, the electrical properties of subcutaneous fat can be calculated from skin dielectric measurements with three probes of different sizes. The three-layer model is based on a variational formula for the capacitance of the coaxial probe. An accurate approximation for the dielectric constant of the multilayer cutaneous structure is presented for the inverse problem of solving the dielectric constants of various layers. The method was tested at 300 MHz with breast cancer patients who often have radiotherapy-induced late alterations in the structure of subcutaneous fat due to the development of subcutaneous fibrosis. Measurements from 206 sites yielded a good agreement between the dielectric constant of subcutaneous fat and the clinical score for subcutaneous fibrosis.
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