The authors analysis of the scientific literature on the problem of craniovertebral abnormalities has been conducted. In this article the history of research on craniovertebral abnormalities, the classification, theories of pathogenesis have been described.
The article investigates the features of urgent complications in patients with malignant lymphoma after chemotherapy. The study included 151 patients. Indolent lymphomas diagnosed in 68 people aggressive lymphomas - in 83 people. The study identified the most important urgent conditions af fecting patients and mortality. In patients with aggressive lymphoma we revealed the following lifethreatening condition (i.e. critical condition under which the patient can die without treatment in the anytime soon): acute heart failure, pulmonary edema, hemorrhagic stroke.The most common urgent conditions in patients with indolent lymphomas are following: ischemic stroke, acute renal failure and DIC syndrome. There were significant predictors of urgent complications that allow to predict their development and define the scope and order of pre-emptive intensive care, as well as to create a matrix of information for the development of learning mathematical matrix for model urgent complications after chemotherapy in patients with malignant lymphoma during neutropenia.
The article presents its own clinical observation of the аssociation of neurotropic herpes viruses with demyelinating process in the central nervous system. An in-depth immunological and immunogenetic examination is carried out as an etiologic and pathogenetic diagnosis.
In recent years, the problem of vascular cognitive impairment is becoming increasingly important due to the increasing prevalence of cerebrovascular disease. The aim of this study was to determine the relationship between 25(OH)D, highly sensitive CRP, interleukin-1, interleukin-6 and cognitive function in patients with cerebrovascular disease and to assess their impact on quality of life.
Materials and methods. 58 patients with cerebrovascular disease aged 3181 years were examined. The comparison group consisted of 24 patients, comparable in age and sex, without the studied pathology. In the study, patients were determined by the level of 25(OH)D, interleukin-1, interleukin-6, highly sensitive CRP in peripheral blood. All patients underwent neuropsychological, psychometric examination and study of their quality of life.
Results. In the study, the level of 25(OH)D in patients with cerebrovascular disease was lower compared to the group without this pathology. Concentrations of interleukin-1, interleukin-6, and highly sensitive CRP in patients in the main group were statistically significantly higher than in those in the comparison group. Higher concentrations of highly sensitive CRP, interleukin-1, and interleukin-6 were found in patients with low vitamin D availability. The study obtained direct correlations between the level of 25(OH)D in peripheral blood and the results of neuropsychological testing (MMSE, MoCA, FAB, Schulte tables (performance), the Drawing hours test) and the inverse with the degree of workability (Schulte tables). An inverse correlation of average strength was observed between the results of psychometric testing and the level of 25(OH)D in peripheral blood. The study confirmed the relationship between the level of 25(OH)D in peripheral blood and quality of life indicators, in the form of a direct correlation.
Conclusion. The study found that the higher the concentration of 25 (OH)D and the lower the level of interleukin-1, interleukin-6, and highly sensitive CRP in the peripheral blood, the less likely it is to develop cognitive and psychoemotional disorders. The study confirmed the relationship between the level of 25(OH)D and quality of life indicators.
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