Out of these 39 cases six cases were of fibroadenoma, used as positive control. Tissue sections were stained with H and E and histological examination was done. Sections for IHC were taken onto poly-l-lysine coated slides and stained by immunoperoxidase method using ER and PR monoclonal antibodies. RESULTS: As evident from study out of 33 cases, 87.88% were IDC (NOS) and two cases (6.06 %) of invasive lobular and mucinous each. Grade was II in 48.49% cases followed by grade III in 30.30 %in remaining 21.21% cases grade was I. Out of 33 cases, 42.42% were ER positive and 33.33% were positive for PR. Correlating with histological grade out of 7 cases of grade I, 85.71 % were positive for both ER and PR. Out of 16 cases of grade II, 25% were ER positive and 31.25% were PR positive and in remaining 10 cases of grade III, 20% were found ER positive and not even a single case was PR positive. CONCLUSION: Histological grading was significantly associated with ER and PR. Hormone receptor immunoreactivity was found inversely correlated with histological grade.
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