Significance of Estrogen and Progesterone Receptor Status in Prognosis of Breast Cancer

Abstract

Out of these 39 cases six cases were of fibroadenoma, used as positive control. Tissue sections were stained with H and E and histological examination was done. Sections for IHC were taken onto poly-l-lysine coated slides and stained by immunoperoxidase method using ER and PR monoclonal antibodies. RESULTS: As evident from study out of 33 cases, 87.88% were IDC (NOS) and two cases (6.06 %) of invasive lobular and mucinous each. Grade was II in 48.49% cases followed by grade III in 30.30 %in remaining 21.21% cases grade was I. Out of 33 cases, 42.42% were ER positive and 33.33% were positive for PR. Correlating with histological grade out of 7 cases of grade I, 85.71 % were positive for both ER and PR. Out of 16 cases of grade II, 25% were ER positive and 31.25% were PR positive and in remaining 10 cases of grade III, 20% were found ER positive and not even a single case was PR positive. CONCLUSION: Histological grading was significantly associated with ER and PR. Hormone receptor immunoreactivity was found inversely correlated with histological grade.