Abstrak. Tanaman kelor mempunyai khasiat sebagai antibakteri. Penambahan ekstrak daun kelor (Moringa oleifera Lamk.) di dalam sediaan gel diperkirakan dapat mempengaruhi stabilitas fisik sediaan tersebut. Penelitian ini bertujuan menguji stabilitas fisik sediaan gel yang mengandung ekstrak daun kelor (Moringa oleifera Lamk.) pada berbagai konsentrasi (1%, 3% dan 5%). Uji stabilitas fisik sedian gel dilakukan setelah penyimpanan selama 14 hari pada suhu ruangan dan uji cycling test (2o±40o C). Parameter stabilitas adalah organoleptis, uji daya sebar, uji daya lekat, pH, viskositas dan cycling test. Hasil ketiga formulasi menunjukkan stabilitas yang sesuai persyaratan sediaan gel diuji pada pengamatan organoleptis, daya sebar, daya lekat, pH, viskositas dan hasil uji cycling test. Kata kunci : Gel, Kelor, Stabilitas Fisik Physical Stability Test Formula Ready Gel Moringa Leaf Extract (Moringa Oleifera Lamk.) Abstract. Moringa plants have efficacy as an antibacterial. The addition of moringa leaf extract (Moringa oleifera Lamk.) preparation required to affect the physical stability of the preparation. The study aims to test the physical stability of gel preparations containing Moringa oleifera Lamk. Leaf extract at various concentrations (1%, 3% and 5%). gel formula physical stability test was carried out after storage for 14 days at room temperature and the cycling test (2o ± 40o C). The stability parameters are organoleptic, dispersion test, adhesion test, pH, viscosity, cycling test. The results of the three formulations showed that stability according to the requirements of the gel preparation. Gel preparation tested on observations of organoleptic, spreadability, adhesion, pH, viscosity, and cycling test results. Keyword: Gel, Moringa, Physical Stability
Bitter gourd as a traditional medicine has a chemical content in its leaves that are useful as antimicrobials and as antioxidants. According to research by Tessa Undap, 2017 shows that bitter melon leaves have an inhibitory power against the growth of Staphylococcus aureus bacteria by inhibiting protein synthesis. The purpose of this study was to determine the antibacterial activity of bitter melon leaf extract (Momordica charantia L.). The research method used in this study is the disc diffusion method. Data was collected by measuring the diameter of the clear zone formed in each treatment. The antibacterial results showed that the 9% extract concentration had the highest inhibitory power.Keywords: Antibacterial, Pare Leaf Extract, Granules, Staphylococcus aureus. AbstrakTanaman pare sebagai obat tradisional memiliki kandungan kimia dalam daunnya yang bermanfaat sebagai antimikroba dan sebagai antioksidan. Menurut penelitian oleh Tessa Undap, 2017 menunjukkan bahwa daun pare mempunyai daya hambat terhadap pertumbuhan bakteri Staphylococcus aureus dengan cara menghambat sintesis protein. Adanya kandungan flavonoid dalam daun pare dapat menghambat pertumbuhan bakteri Staphylococcus aureus yang dapat mengkoagulasi protein pada sel bakteri. Tujuan dari penelitian ini yaitu untuk mengetahui aktivitas antibakteri yang terkandung dalam ekstrak daun pare (Momordica charantia L.). Metode penelitian yang digunakan dalam penelitian ini yaitu metode difusi cakram disk. Pengumpulan data dilakukan dengan cara mengukur diameter zona bening yang terbentuk pada setiap perlakuan. Hasil antibakteri yaitu menunjukkan bahwa konsentrasi ekstrak 9% mempunyai daya hambat paling tinggi.Kata kunci: Antibakteri, Ekstrak Daun Pare, Granul, Staphylococcus aureus.
Background: The COVID-19 vaccine still has a poor vaccination rate among pregnant women for a variety of reasons, one of which is a lack of knowledge about the vaccine's advantages as well as the potential side effects and risks that may result from the vaccine. The purpose of this research is to discover determinant factors that influence Covid-19 vaccination willingness. Methods: This is a descriptive analytic study with a chronological method. In this study, a total population of 255 pregnant women was sampled, using the first dose of COVID-19 vaccination administered to pregnant women at Kedungwuni II Health Center. This research relies on primary data and a questionnaire that has been assessed for validity and reliability. This study lasted six months, from July to December 2021. The analysis was a multivariate logistic regression analysis. Results: The factors related to the willingness of pregnant women to take part in the COVID-19 vaccination were age (p=0.026), gravida status (p=0.029), ANC frequency (p=0.002) and knowledge about covid 19 vaccination (p=0.001). Conclusion: It is critical for healthcare practitioners to provide information about the COVID -19 vaccination so that expectant mothers do not feel anxious about going to the vaccination sites. Pregnant women should also be informed about the possibility of post-vaccination complications.
Abstrak Diabetes mellitus merupakan salah satu penyakit yang berpotensi tinggi menyebabkan munculnya penyakit lain misalnya penyakit komplikasi kardiovaskuler. Penyakit yang muncul diantaranya stroke, hipertensi, dan hiperlipidemia. Terapi pengobatan pada pasien diabetes mellitus menggunakan antidiabetika oral dan atau insulin untuk menurunkan kadar gula darah mencapai normal. Tujuan penelitian ini untuk mengetahui potensi penyakit penyerta pada pengobatan pasien diabetes mellitus. Metode penelitian ini menggunakan pendekatan cross sectional secara observasional non-eksperimental yang bersifat retrospektif. Data yang diambil yaitu data rekam medis pasien diabetes melitus tipe 2 yang mendapat terapi obat antidiabetik oral (ADO) di RSUD Kajen Kabupaten Pekalongan. Sebanyak 97 sampel, dianalisis secara deskriptif. Hasil penelitian didapatkan bahwa sebesar 61,86 % pasien diabetes mellitus tanpa disertai penyakit penyerta dan sebesar 38,14 % pasien diabetes mellitus disertai penyakit penyerta. Penyakit hipertensi yang muncul sebesar 78,38 %, hiperlipidemia yang muncul sebesar 16,22 %, dan stroke yang muncul sebesar 5,4 %. berpotensi muncul pada pasien diabetes mellitus.Kata kunci : Diabetes melitus, antidiabetik oral, hipertensi, hiperlipidemia, strokeThe Potential Of Disease In Patients Of Diabetes Mellitus Perspective Towards Oral Antidiabetics AbstractDiabetes mellitus is a disease that has high potential to cause other diseases such as cardiovascular complications. Diseases that arise include stroke, hypertension, and hyperlipidemia. Treatment therapy in patients with diabetes mellitus using oral antidiabetika and or insulin to reduce blood sugar levels to normal. The purpose of this study was to determine the potential for comorbidities in the treatment of patients with diabetes mellitus. This research method uses a non-experimental observational cross sectional approach that is retrospective in nature. The data taken is the medical record data of type 2 diabetes mellitus patients who received oral antidiabetic drug therapy (ADO) at Kajen District Hospital in Pekalongan Regency. A total of 97 samples were analyzed descriptively. The results showed that 61.86% of diabetes mellitus patients without accompanying diseases and 38.14% of diabetes mellitus patients accompanied by concomitant diseases. Hypertension is 78.38%, hyperlipidemia is 16.22%, and stroke is 5.4%. potentially appear in patients with diabetes mellitus.Keywords: Diabetes mellitus, oral antidiabetic, hypertension, hyperlipidemia, stroke
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