Improving
the stability of fucoxanthin in the gastrointestinal
tract is an important approach to enhance its oral bioavailability.
The study proposed a new microfluidic device allowing for the synthesis
of a structurally well-defined nanoscale delivery system with a uniform
size for encapsulation and colon-target release of fucoxanthin. The
rapid mixing in the microfluidic channel ensured that the mixing time
was shorter than the aggregation time, thus realizing the controllable
control of the coprecipitation of fucoxanthin and shellac polymer.
In vitro digestion tests showed that a pH stimulus-responsive release
of fucoxanthin from FX/SH NPs was observed under alkaline pH conditions.
The fluorescence colocalization imaging indicated that FX/SH NPs did
not affect the intestine function and had a protective effect on Caco-2
cells damaged by H2O2 by enhancing their antioxidant
capacity. Overall, this work illustrated the promise of using a microfluidic
approach to fabricate the biomimetic nanodelivery system for better
biocompatibility and targeting efficacy.
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