Advances of microfluidic intestine-on-a-chip for analyzing anti-inflammation of food

Liang, Duo; Su, Wentao; Tan, Mingqian

doi:10.1080/10408398.2021.1875395

Cited by 17 publications

(13 citation statements)

References 132 publications

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“…Therefore, these nanodrug delivery systems are usually injected subcutaneously or intravenously into the human body as drugs and are not suitable for oral colonic administration of fucoxanthin. According to the characteristics of high acidity in the stomach, near neutral in the proximal small intestine, and weak alkaline in the terminal ileum, it is of great significance to explore a simple preparation method of a nanoscale delivery system with pH-responsive food-grade raw materials as wall materials for targeted delivery of fucoxanthin. − …”

Section: Introductionmentioning

confidence: 99%

Microfluidic Fabrication of pH-Responsive Nanoparticles for Encapsulation and Colon-Target Release of Fucoxanthin

Liang

Zhao

et al. 2021

J. Agric. Food Chem.

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Improving the stability of fucoxanthin in the gastrointestinal tract is an important approach to enhance its oral bioavailability. The study proposed a new microfluidic device allowing for the synthesis of a structurally well-defined nanoscale delivery system with a uniform size for encapsulation and colon-target release of fucoxanthin. The rapid mixing in the microfluidic channel ensured that the mixing time was shorter than the aggregation time, thus realizing the controllable control of the coprecipitation of fucoxanthin and shellac polymer. In vitro digestion tests showed that a pH stimulus-responsive release of fucoxanthin from FX/SH NPs was observed under alkaline pH conditions. The fluorescence colocalization imaging indicated that FX/SH NPs did not affect the intestine function and had a protective effect on Caco-2 cells damaged by H2O2 by enhancing their antioxidant capacity. Overall, this work illustrated the promise of using a microfluidic approach to fabricate the biomimetic nanodelivery system for better biocompatibility and targeting efficacy.

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Section: Introductionmentioning

confidence: 99%

Microfluidic Fabrication of pH-Responsive Nanoparticles for Encapsulation and Colon-Target Release of Fucoxanthin

Liang

Zhao

et al. 2021

J. Agric. Food Chem.

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“…The intestinal epithelial barrier is covered by the glycoprotein mucus, which plays a key role in the absorption and transportation of food ingredients. 33 In order to investigate the retention effect of membrane vesicles in the intestine, mice were fed with Nile-red MVs and free Nile red at a series of predetermined time points, and the mice intestines were collected to obseve the retention effect of the samples in the intestine through fluorescence. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Engineering probiotics-derived membrane vesicles for encapsulating fucoxanthin: evaluation of stability, bioavailability, and biosafety

Liang

Liu

et al. 2023

Food Funct.

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“…Although the applications of gut‐on‐chip models are still at the initial phases of development, they hold great potential for exploring the interactions between host, microbiome, and nutrition (Garcia‐Gutierrez & Cotter, 2022; D. Liang et al., 2022; Siwczak et al., 2021; Wu et al., 2023).…”

Section: Nams For Nutrition Researchmentioning

confidence: 99%

Human‐based new approach methodologies to accelerate advances in nutrition research

Cassotta,

Cianciosi,

Elexpuru‐Zabaleta

et al. 2024

Food Frontiers

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Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models have undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three‐dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human‐based and more physiologically relevant tools. These tools, also known as “new approach methodologies,” which comprise patient‐derived organoids, organs‐on‐chip, multi‐omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human‐biology‐oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human‐relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm‐change toward a more human biology‐focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research.

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Advances of microfluidic intestine-on-a-chip for analyzing anti-inflammation of food

Cited by 17 publications

References 132 publications

Microfluidic Fabrication of pH-Responsive Nanoparticles for Encapsulation and Colon-Target Release of Fucoxanthin

Microfluidic Fabrication of pH-Responsive Nanoparticles for Encapsulation and Colon-Target Release of Fucoxanthin

Engineering probiotics-derived membrane vesicles for encapsulating fucoxanthin: evaluation of stability, bioavailability, and biosafety

Human‐based new approach methodologies to accelerate advances in nutrition research

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