These data show that lowered HRQoL in major affective disorders could at least in part result from the effects of lipid peroxidation, protein oxidation, lowered antioxidant enzyme activities, and higher levels of TSH.

Aim: There are prominent discrepancies in the general approaches of psychology and psychiatry, many of them due to diverse and incompatible tacit positions on the mind-brain debate (MBD). For this reason we need to enhance the dialogue with neurosciences and other human sciences relevant to the problems of psychopathology. To achieve such goal we can reduce the level of diversity of mind-brain problem project-solutions as implied in different theoretical models and practices. Arguments: I shall trace the MBD to the one of the most relevant for the modern psychopathology areas: the group of neurosciences. We seek the interference of the philosophical assumptions, the evidence of neuroscience and the development of psychopathology. We prove by a post rem analysis that the reduced group of predominant project-solutions of MBD excludes genuine forms of dualism and extreme forms of physicalism (like epiphenomenalism or eliminative materialism). Conclusion: A predominant group of project-solutions is adopted including complementary combination of contemporary forms of physicalism: identity theory of mind applied to mental events and brain processes; supervenience principle applied to other mental phenomena. Biomed Rev 2011; 22: 65-76.

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